2-羧基-3-硝基苯甲酸乙酯合成路线 （共 17 条）
反应条件
1: SOCl2 / 1 h / Heating 2: aq. NaN3 / acetone / 1 h / below 25 deg C 3: aq. AcOH / 0.17 h / Heating 4: aq. KOH / Heating 5: H2, aq. NaOH / Pd/C 6: cupric acetate, AcOH / H2O; methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 2 p. 814 - 819
反应条件
1: SOCl2 / 1 h / Heating 2: aq. NaN3 / acetone / 1 h / below 25 deg C 3: aq. AcOH / 0.17 h / Heating 4: aq. KOH / Heating 5: H2, aq. NaOH / Pd/C 6: cupric acetate, AcOH / H2O; methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 2 p. 814 - 819
反应条件
1: SOCl2 / 1 h / Heating 2: aq. NaN3 / acetone / 1 h / below 25 deg C 3: aq. AcOH / 0.17 h / Heating 4: aq. KOH / Heating 5: H2, aq. NaOH / Pd/C 6: cupric acetate, AcOH / H2O; methanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 2 p. 814 - 819
反应条件
1: SOCl2 / 1 h / Heating 2: aq. NaN3 / acetone / 1 h / below 25 deg C 3: aq. AcOH / 0.17 h / Heating 4: aq. KOH / Heating 5: 1.) cupric acetate, 2.) aq. Na2S, concd. HCl / 1.) H2O, MeOH, reflux, 2.) EtOH View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 2 p. 814 - 819
反应条件
1: SOCl2 / 1 h / Heating 2: aq. NaN3 / acetone / 1 h / below 25 deg C 3: aq. AcOH / 0.17 h / Heating 4: aq. KOH / Heating 5: H2, aq. NaOH / Pd/C 6: cupric acetate, AcOH / H2O; methanol / Heating View Scheme
参考文献
Denny, William A.; Rewcastle, Gordon W.; Baguley, Bruce C.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 814 - 819
反应条件
thionyl chloride in dimethylformamide(DMF); dichloromethane; diethyl ether hexane; water; tert-butyl alcohol; benzene
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5128356 A1, 1992 ;
反应条件
1: SOCl2 / 1 h / Heating
2: aq. NaN3 / acetone / 1 h / below 25 deg C
3: aq. AcOH / 0.17 h / Heating
View Scheme
参考文献
Denny, William A.; Rewcastle, Gordon W.; Baguley, Bruce C.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 814 - 819
