4-溴-3,5-二羟基苯甲酸合成路线 （共 20 条）
反应条件
1: potassium carbonate; dimethyl sulfate / acetone / 24 h / |Reflux; |Inert atmosphere 2: lithium aluminium tetrahydride / tetrahydrofuran / 8.25 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
Saeed, Aamer; Mahesar, Parvez Ali
Tetrahedron, 2014 , vol. 70, # 7 p. 1401 - 1407
反应条件
1: 75 percent / K2CO3 / dimethylformamide / 20 h / Ambient temperature 2: 95 percent / NaOH / H2O / 12 h / 100 °C 3: 99 percent / CDI, DBU / dimethylformamide / 60 h / 40 °C View Scheme
参考文献
Lampe, John W.; Hughes, Philip F.; Biggers, Christopher K.; Smith, Shelley H.; Hu, Hong
Journal of Organic Chemistry, 1994 , vol. 59, # 18 p. 5147 - 5148
反应条件
potassium carbonate in N,N-dimethyl-formamide T=25°C; 4 h;
参考文献
Nicolaou; Bunnage; Bunnage, Mark E.; Koide; Koide, Kazunori
Journal of the American Chemical Society, 1994 , vol. 116, # 18 p. 8402 - 8403
Title/Abstract Full Text View citing articles Show Details
Nicolaou, K. C.; Koide, Kazunori; Bunnage, Mark E.
Chemistry--A European Journal, 1995 , vol. 1, # 7 p. 454 - 466
反应条件
1: 97 percent / K2CO3 / dimethylformamide / 15 h / 20 °C 2: 47 percent / lithium aluminum hydride / tetrahydrofuran / 2 h / 0 °C 3: 94 percent / pyridinium chlorochromate; celite; sodium acetate / CH2Cl2 / 4.5 h / 0 °C View Scheme
参考文献
Pelish; Westwood; Feng; Kirchhausen; Shair
Journal of the American Chemical Society, 2001 , vol. 123, # 27 p. 6740 - 6741
反应条件
thionyl chloride 2 h; Heating;
参考文献
Boccalon, Mariangela; Iengo, Elisabetta; Tecilla, Paolo
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 24 p. 4056 - 4067
反应条件
2: (i) SOCl2, (ii) Li<AlH(OtBu)3> 3: NH4OAc / acetic acid 4: LiAlH4 View Scheme
参考文献
Barfknecht; Nichols
Journal of medicinal chemistry, 1971 , vol. 14, # 4 p. 370 - 372
反应条件
1: 75 percent / K2CO3 / dimethylformamide / 20 h / Ambient temperature 2: 95 percent / NaOH / H2O / 12 h / 100 °C View Scheme
参考文献
Lampe, John W.; Hughes, Philip F.; Biggers, Christopher K.; Smith, Shelley H.; Hu, Hong
Journal of Organic Chemistry, 1994 , vol. 59, # 18 p. 5147 - 5148
反应条件
1: With ethanol; sulfuric acid
2: With dimethylsulfide borane complex
参考文献
Azagarsamy, Malar A.; Krishnamoorthy, Kothandam; Sivanandan, Kulandaivelu; Thayumanavan
Journal of Organic Chemistry, 2009 , vol. 74, # 24 p. 9475 - 9485
参考文献
Fisons Limited
Patent: US4172960 A1, 1979 ;
反应条件
2: SOCl2
View Scheme
参考文献
Barfknecht; Nichols
Journal of medicinal chemistry, 1971 , vol. 14, # 4 p. 370 - 372
