1: ethyl 2-oxo-cyclohexanecarboxylate With potassium hydroxide in water T=30°C; 4 h; 2: aniline With hydrogenchloride; sodium nitrite in water T=0°C; 1 h; Further stages;
参考文献
LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN; INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY; HONARNEJAD, Kamran; DASCHNER, Alexander; HERMS, Jochen; BRACHER, Franz; KUZNICKI, Jacek; GEHRING, André Philipe
Patent: WO2013/139929 A1, 2013 ;
Location in patent: Page/Page column 44; 45 ;
1: ethyl 2-oxo-cyclohexanecarboxylate With potassium hydroxide in water T=0 - 30°C; Japp-Klingemann reaction; 4 h; 2: benzene diazonium chloride in water T=0°C; Japp-Klingemann reaction; 3: With formic acid in water T=80°C; Fischer cyclization; 12 h;
参考文献
Gehring, Andrep.; Bracher, Franz
Synthesis (Germany), 2012 , vol. 44, # 15 p. 2441 - 2447
1.1: aq. NaOH / 48 h / 20 °C 1.2: 92 percent / H2O / 0 - 20 °C 2.1: 92 percent / aq. H2SO4 / acetonitrile / 80 °C View Scheme
参考文献
Hillier, Michael C.; Marcoux, Jean-Francois; Zhao, Dalian; Grabowski, Edward J. J.; McKeown, Arlene E.; Tillyer, Richard D.
Journal of Organic Chemistry, 2005 , vol. 70, # 21 p. 8385 - 8394
