反应条件
1.1: ytterbium(III) triflate / n-heptane / 3 h / Reflux 2.1: sodium tetrahydroborate; acetic acid / acetonitrile / 2 - 22 °C / Inert atmosphere 2.2: pH ~ 8 3.1: sodium t-butanolate / tert-butyl alcohol; tetrahydrofuran / 5 h / 6 - 22 °C / Inert atmosphere 4.1: lithium borohydride / tetrahydrofuran / 12 h / 15 °C / Reflux; Inert atmosphere 4.2: 0.5 h / 5 - 15 °C 4.3: pH ~ 8.7 5.1: sodium carbonate / acetonitrile / 18 h / Reflux; Inert atmosphere 6.1: triethylamine / dichloromethane / 1.42 h / 2 - 22 °C / Inert atmosphere 7.1: sodium t-butanolate / tetrahydrofuran / 1 h / 19 - 65 °C / Inert atmosphere 8.1: hydrogen / 5 Pd(II)/C(eggshell) / ethanol / 3 h / 60 °C / 749.88 Torr 9.1: hydrogenchloride; water / 4 h / Reflux 10.1: thionyl chloride / dichloromethane View Scheme
参考文献
ABBOTT LABORATORIES; CHEMBURKAR, Sanjay, R.; REDDY, Rajarathman, E.; REAMER, Douglas, M.; PAVLINA, John, T.; ULREY, Stephen, S.; KOTECKI, Brian, J.
Patent: WO2011/9021 A1, 2011 ;
