反应条件
1: bromine / chloroform
2: thionyl chloride
3: AlCl3, aluminium chloride
4: sodium hydroxide
5: S-(-)-N-methyl-alpha-methylbenzylamine / isopropanol acetate / 20 - 23 °C / Resolution of racemate
6: sodium hydrogencarbonate / N,N-dimethyl-formamide
7: tetrakis(triphenylphosphine) palladium(0); potassium fluoride / ethanol; water; N,N-dimethyl-formamide; toluene
8: iron; ammonium chloride
View Scheme
参考文献
Ravn, Matthew M.; Wagaw, Seble H.; Engstrom, Kenneth M.; Mei, Jianzhang; Kotecki, Brian; Souers, Andrew J.; Kym, Philip R.; Judd, Andrew S.; Zhao, Gang
Organic Process Research and Development, 2010 , vol. 14, # 2 p. 417 - 424