2-甲氧基-6-硝基苯胺合成路线 （共 28 条）
参考文献
Blanksma
Chem. Zentralbl., 1908 , vol. 79, # II p. 1826
反应条件
1: hydrogen; palladium 10 on activated carbon / ethanol / 2 h / 20 °C 2: 4 h / |Reflux View Scheme
参考文献
Zhou, Jie; Jin, Jing; Zhang, Yi; Yin, Yuwen; Chen, Xiaoguang; Xu, Bailing
European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 222 - 232
反应条件
1: Diazotization 2: aqueous HCl / 160 °C View Scheme
参考文献
van Erp
Journal fuer Praktische Chemie (Leipzig), 1930 , vol. <2> 127, p. 20,22
反应条件
1: With hydrogen bromide; sodium nitrite in water T=0°C; 0.666667 h; 2: With copper(I) bromide in water T=0 - 60°C; 2 h; Heating / reflux;
参考文献
Schumacher, Richard; Danca, Mihaela Diana; Ma, Jianguo; Herbert, Brian; Nguyen, True Minh; Xie, Wenge; Tehim, Ashok
Patent: US2007/78147 A1, 2007 ;
Location in patent: Page/Page column 67 ;
反应条件
1: NaNO2; aq. H2SO4; CuBr / aq. HBr 2: Fe; aq. HCl / ethanol View Scheme
参考文献
Ando,M.; Emoto,S.
Bulletin of the Chemical Society of Japan, 1978 , vol. 51, p. 2437 - 2438
反应条件
2: platinum; ethanol / Hydrogenation.Behandeln der Reaktionsloesung mit wss. HCl und Behandeln des Reaktionsprodukts in H2O mit FeCl3 View Scheme
参考文献
Clemo; Daglish
Journal of the Chemical Society, 1950 , p. 1481,1483
反应条件
bromine; sodium acetate in acetic acid
T=20°C; 0.333333 h;
参考文献
Qu, Junya; Rivero, Ralph; Sanchez, Robert; Tedesco, Rosanna
Patent: US2012/88767 A1, 2012 ;
Location in patent: Page/Page column 16; 22 ;
反应条件
1.1: sodium acetate; bromine / acetic acid / 0.25 h / 20 °C
2.1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 °C
3.1: hydrogen; platinum on activated charcoal / ethanol / 0.75 h / 750.08 Torr
4.1: trifluoroacetic acid / dichloromethane / 20 °C
4.2: pH 9
5.1: trifluoroacetic acid / dichloromethane / 20 °C
5.2: pH 9
View Scheme
参考文献
H. LUNDBECK A/S; JØRGENSEN, Morten; BRUUN, Anne Techau; RASMUSSEN, Lars Kyhn
Patent: WO2013/34758 A1, 2013 ;
