3,9-二甲氧基-5,8,13,13alpha-四氢-6H-异喹啉并[3,2-a]异喹啉-2,10-二醇合成路线 （共 34 条）
反应条件
hydrogenchloride in ethanol; water 2 h; Reflux;
参考文献
Sun, Haifeng; Zhu, Liyuan; Yang, Huicui; Qian, Wangke; Guo, Lin; Zhou, Shengbin; Gao, Bo; Li, Zeng; Zhou, Yu; Jiang, Hualiang; Chen, Kaixian; Zhen, Xuechu; Liu, Hong
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 856 - 868
反应条件
boron trichloride in dichloromethane T=-78 - 20°C; Inert atmosphere; optical yield given as percent ee;
参考文献
Cheng, Jianjun; Fu, Liqiang; Ling, Chenyu; Yang, Yushe
Heterocycles, 2010 , vol. 81, # 11 p. 2581 - 2592
反应条件
palladium 10 on activated carbon; hydrogen in methanol 2 h;
参考文献
Journal of Organic Chemistry, , vol. 74, # 23 p. 9225 - 9228
反应条件
1.1: titanium(IV) isopropylate / tetrahydrofuran / 4 h / Inert atmosphere; Reflux 2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 2.2: 0.67 h / -78 - -60 °C / Inert atmosphere 3.1: hydrogenchloride; water / methanol / 2 h / 20 °C 4.1: potassium hydroxide / ethanol; water / 12 h / Reflux 5.1: pyridine / 20 °C 6.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 7.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 8.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme
参考文献
Heterocycles, , vol. 81, # 11 p. 2581 - 2592
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -10 °C / Inert atmosphere 1.2: -78 - 20 °C / Inert atmosphere 2.1: palladium 10 on activated carbon; hydrogen / methanol / 8 h / 20 °C / 760.05 Torr 3.1: water / ethanol / 4 h / Reflux 4.1: oxalyl dichloride / 2 h / Reflux 5.1: ammonium hydroxide / diethyl ether / 1 h / 0 - 20 °C 6.1: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 16 h / 20 °C 7.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 7.2: 0.67 h / -78 - -60 °C / Inert atmosphere 8.1: hydrogenchloride; water / methanol / 2 h / 20 °C 9.1: potassium hydroxide / ethanol; water / 12 h / Reflux 10.1: pyridine / 20 °C 11.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 12.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 13.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme
参考文献
Heterocycles, , vol. 81, # 11 p. 2581 - 2592
反应条件
1.1: palladium 10 on activated carbon; hydrogen / methanol / 8 h / 20 °C / 760.05 Torr 2.1: water / ethanol / 4 h / Reflux 3.1: oxalyl dichloride / 2 h / Reflux 4.1: ammonium hydroxide / diethyl ether / 1 h / 0 - 20 °C 5.1: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 16 h / 20 °C 6.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 6.2: 0.67 h / -78 - -60 °C / Inert atmosphere 7.1: hydrogenchloride; water / methanol / 2 h / 20 °C 8.1: potassium hydroxide / ethanol; water / 12 h / Reflux 9.1: pyridine / 20 °C 10.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 11.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 12.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme
参考文献
Heterocycles, , vol. 81, # 11 p. 2581 - 2592
反应条件
1.1: water / ethanol / 4 h / Reflux 2.1: oxalyl dichloride / 2 h / Reflux 3.1: ammonium hydroxide / diethyl ether / 1 h / 0 - 20 °C 4.1: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 16 h / 20 °C 5.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 5.2: 0.67 h / -78 - -60 °C / Inert atmosphere 6.1: hydrogenchloride; water / methanol / 2 h / 20 °C 7.1: potassium hydroxide / ethanol; water / 12 h / Reflux 8.1: pyridine / 20 °C 9.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 10.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 11.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme
参考文献
Heterocycles, , vol. 81, # 11 p. 2581 - 2592
反应条件
1.1: oxalyl dichloride / 2 h / Reflux 2.1: ammonium hydroxide / diethyl ether / 1 h / 0 - 20 °C 3.1: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 16 h / 20 °C 4.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 4.2: 0.67 h / -78 - -60 °C / Inert atmosphere 5.1: hydrogenchloride; water / methanol / 2 h / 20 °C 6.1: potassium hydroxide / ethanol; water / 12 h / Reflux 7.1: pyridine / 20 °C 8.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 9.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 10.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme
参考文献
Heterocycles, , vol. 81, # 11 p. 2581 - 2592
反应条件
1.1: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 16 h / 20 °C 2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 2.2: 0.67 h / -78 - -60 °C / Inert atmosphere 3.1: hydrogenchloride; water / methanol / 2 h / 20 °C 4.1: potassium hydroxide / ethanol; water / 12 h / Reflux 5.1: pyridine / 20 °C 6.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 7.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 8.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme
参考文献
Heterocycles, , vol. 81, # 11 p. 2581 - 2592
反应条件
1.1: N-bromosuccinmide / N,N-dimethyl-formamide / 12 h / 0 - 20 °C 2.1: 1H-imidazole / dichloromethane / 1 h / 20 °C 3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 3.2: 0.33 h / -78 - 0 °C / Inert atmosphere 4.1: titanium(IV) isopropylate / tetrahydrofuran / 4 h / Inert atmosphere; Reflux 5.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 5.2: 0.67 h / -78 - -60 °C / Inert atmosphere 6.1: hydrogenchloride; water / methanol / 2 h / 20 °C 7.1: potassium hydroxide / ethanol; water / 12 h / Reflux 8.1: pyridine / 20 °C 9.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 10.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 11.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme
参考文献
Heterocycles, , vol. 81, # 11 p. 2581 - 2592
