1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 1.2: 0.67 h / -78 - -60 °C / Inert atmosphere 2.1: hydrogenchloride; water / methanol / 2 h / 20 °C 3.1: potassium hydroxide / ethanol; water / 12 h / Reflux 4.1: pyridine / 20 °C 5.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 7.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme

1: hydrogenchloride; water / methanol / 2 h / 20 °C 2: potassium hydroxide / ethanol; water / 12 h / Reflux 3: pyridine / 20 °C 4: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 5: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 6: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme

1: potassium hydroxide / ethanol; water / 12 h / Reflux 2: pyridine / 20 °C 3: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 5: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme

1: pyridine / 20 °C 2: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 4: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 2: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme

1.1: 1H-imidazole / dichloromethane / 1 h / 20 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 2.2: 0.33 h / -78 - 0 °C / Inert atmosphere 3.1: titanium(IV) isopropylate / tetrahydrofuran / 4 h / Inert atmosphere; Reflux 4.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 4.2: 0.67 h / -78 - -60 °C / Inert atmosphere 5.1: hydrogenchloride; water / methanol / 2 h / 20 °C 6.1: potassium hydroxide / ethanol; water / 12 h / Reflux 7.1: pyridine / 20 °C 8.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 9.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 10.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 1.2: 0.33 h / -78 - 0 °C / Inert atmosphere 2.1: titanium(IV) isopropylate / tetrahydrofuran / 4 h / Inert atmosphere; Reflux 3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 3.2: 0.67 h / -78 - -60 °C / Inert atmosphere 4.1: hydrogenchloride; water / methanol / 2 h / 20 °C 5.1: potassium hydroxide / ethanol; water / 12 h / Reflux 6.1: pyridine / 20 °C 7.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 8.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 9.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme

1.1: titanium(IV) isopropylate; triethylamine / ethanol / 16 h / 30 °C 1.2: 14 h 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -10 °C / Inert atmosphere 2.2: -78 - 20 °C / Inert atmosphere 3.1: palladium 10 on activated carbon; hydrogen / methanol / 8 h / 20 °C / 760.05 Torr 4.1: water / ethanol / 4 h / Reflux 5.1: oxalyl dichloride / 2 h / Reflux 6.1: ammonium hydroxide / diethyl ether / 1 h / 0 - 20 °C 7.1: 2,4,6-trichloro-1,3,5-triazine / N,N-dimethyl-formamide / 16 h / 20 °C 8.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 8.2: 0.67 h / -78 - -60 °C / Inert atmosphere 9.1: hydrogenchloride; water / methanol / 2 h / 20 °C 10.1: potassium hydroxide / ethanol; water / 12 h / Reflux 11.1: pyridine / 20 °C 12.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 13.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 14.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Reflux 2.1: N-bromosuccinmide / N,N-dimethyl-formamide / 12 h / 0 - 20 °C 3.1: 1H-imidazole / dichloromethane / 1 h / 20 °C 4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 4.2: 0.33 h / -78 - 0 °C / Inert atmosphere 5.1: titanium(IV) isopropylate / tetrahydrofuran / 4 h / Inert atmosphere; Reflux 6.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 6.2: 0.67 h / -78 - -60 °C / Inert atmosphere 7.1: hydrogenchloride; water / methanol / 2 h / 20 °C 8.1: potassium hydroxide / ethanol; water / 12 h / Reflux 9.1: pyridine / 20 °C 10.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C 11.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Inert atmosphere; Reflux 12.1: boron trichloride / dichloromethane / -78 - 20 °C / Inert atmosphere View Scheme

1: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C 2: hydrogenchloride / water; ethanol / 2 h / |Reflux View Scheme