copper(l) iodide in N,N-dimethyl-formamide T=100°C; Cyclization; 2.5 h;

1: 95 percent / bis(pyridine)iodonium(I) tetrafluoroborate; CF3SO3H / CH2Cl2 / 72 h / 20 °C 2: 89 percent / Et3N / Pd(PPh3)2Cl2-CuI / 3 h / 0 - 20 °C 3: 55 percent / CuI / dimethylformamide / 2.5 h / 100 °C View Scheme

1: 89 percent / Et3N / Pd(PPh3)2Cl2-CuI / 3 h / 0 - 20 °C 2: 55 percent / CuI / dimethylformamide / 2.5 h / 100 °C View Scheme

NADPH in phosphate buffer T=37°C; pH=7.4; 0.166667 h; Enzyme kinetics;