[(1S)-1-(2S)-环氧乙烷基乙基]-氨基甲酸叔丁酯合成路线 （共 8 条）
反应条件
potassium carbonate in methanol T=0 - 20°C; 1.5 h;
参考文献
Allepuz, Ana C.; Badorrey, Ramon; Diaz-de-Viliegas, Maria D.; Galvez, Jose A.
European Journal of Organic Chemistry, 2009 , # 35 p. 6172 - 6178
反应条件
potassium hydroxide in ethanol T=20°C;
参考文献
Nadin, Alan; Owens, Andrew P.; Castro, Jose L.; Harrison, Timothy; Shearman, Mark S.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 37 - 41
反应条件
triphenylphosphine; diethylazodicarboxylate in chloroform Epoxidation; Mitsunobu reaction; Heating;
参考文献
Aguilar, Nuria; Moyano, Albert; Pericas, Miquel A.; Riera, Antoni
Tetrahedron Letters, 1999 , vol. 40, # 20 p. 3913 - 3916
反应条件
1: LDA / tetrahydrofuran / -90 °C 2: NaBH4 / toluene; ethanol / -78 - 20 °C 3: 100 percent / KOH / ethanol / 20 °C View Scheme
参考文献
Nadin, Alan; Owens, Andrew P.; Castro, Jose L.; Harrison, Timothy; Shearman, Mark S.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 37 - 41
反应条件
1: NaBH4 / toluene; ethanol / -78 - 20 °C 2: 100 percent / KOH / ethanol / 20 °C View Scheme
参考文献
Nadin, Alan; Owens, Andrew P.; Castro, Jose L.; Harrison, Timothy; Shearman, Mark S.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 37 - 41
反应条件
potassium hydroxide; triethylamine 1) THF, room temperature, 2.5 h, 2) THF, MeOH, room temperature, 20 min; Yield given. Multistep reaction;
参考文献
Beaulieu, Pierre L.; Wernic, Dominik
Journal of Organic Chemistry, 1996 , vol. 61, # 11 p. 3635 - 3645
反应条件
1: n-tetradecylmagnesium chloride With copper(l) iodide in tetrahydrofuran
T=0°C; Inert atmosphere;
2: (S)-1-lt;(S)-1-(tert-butoxycarbonylamino)ethylgt;oxirane in tetrahydrofuran
T=0°C; Inert atmosphere;
参考文献
Allepuz, Ana C.; Badorrey, Ramon; Diaz-de-Viliegas, Maria D.; Galvez, Jose A.
European Journal of Organic Chemistry, 2009 , # 35 p. 6172 - 6178
反应条件
1: n-tetradecylmagnesium chloride With copper (I) cyanide in tetrahydrofuran
T=0°C; Inert atmosphere;
2: (S)-1-lt;(S)-1-(tert-butoxycarbonylamino)ethylgt;oxirane in tetrahydrofuran
T=0°C; Inert atmosphere;
参考文献
Allepuz, Ana C.; Badorrey, Ramon; Diaz-de-Viliegas, Maria D.; Galvez, Jose A.
European Journal of Organic Chemistry, 2009 , # 35 p. 6172 - 6178
