4,4'-亚乙基二苯甲醚合成路线 （共 130 条）
反应条件
copper(l) iodide; chloro-trimethyl-silane; iodine; lanthanum in acetonitrile
T=82°C; 1 h;
参考文献
Nishino, Toshiki; Nishiyama, Yutaka; Sonoda, Noboru
Bulletin of the Chemical Society of Japan, 2003 , vol. 76, # 3 p. 635 - 641
反应条件
indium in N,N-dimethyl-formamide
8 h; Heating;
参考文献
Ranu, Brindaban C.; Dutta, Pinak; Sarkar, Arunkanti
Tetrahedron Letters, 1998 , vol. 39, # 51 p. 9557 - 9558
反应条件
manganese in tetrahydrofuran
T=20°C; 0.0833333 h;
参考文献
Barrero, Alejandro F.; Herrador, M. Mar; Del Moral, Jose F. Quilez; Arteaga, Pilar; Akssira, Mohammed; El Hanbali, Fadwa; Arteaga, Jesus F.; Dieguez, Horacio R.; Sanchez, Elena M.
Journal of Organic Chemistry, 2007 , vol. 72, # 6 p. 2251 - 2254
反应条件
dipotassium hydrogenphosphate; silver nitrate; zinc in water
T=30°C; 1 h;
参考文献
Bieber, Lothar W.; Storch, Elisabeth C.; Malvestiti, Ivani; Da Silva, Margarete F.
Tetrahedron Letters, 1998 , vol. 39, # 51 p. 9393 - 9396
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 20 °C
1.2: tetrahydrofuran; hexane / 2 h / 20 °C
2.1: 95 percent / H2 / Pd/C / methanol / 3 h / 760 Torr
View Scheme
参考文献
Oh, Ki-Bong; Kim, Soo-Hwan; Lee, Jaekwang; Cho, Won-Jea; Lee, Taeho; Kim, Sanghee
Journal of Medicinal Chemistry, 2004 , vol. 47, # 10 p. 2418 - 2421
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / 20 °C
1.2: tetrahydrofuran; hexane / 2 h / 20 °C
2.1: 95 percent / H2 / Pd/C / methanol / 3 h / 760 Torr
View Scheme
参考文献
Oh, Ki-Bong; Kim, Soo-Hwan; Lee, Jaekwang; Cho, Won-Jea; Lee, Taeho; Kim, Sanghee
Journal of Medicinal Chemistry, 2004 , vol. 47, # 10 p. 2418 - 2421
反应条件
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature
2: 69 percent / PPA / 1 h / 85 - 90 °C
3: 100 percent / W-2 Raney Ni / ethanol / 0.5 h / Heating
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 69 percent / PPA / 1 h / 85 - 90 °C
2: 100 percent / W-2 Raney Ni / ethanol / 0.5 h / Heating
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 80.4 percent / KOH / ethanol; H2O; ethyl acetate / Ambient temperature
2: 69 percent / PPA / 1 h / 85 - 90 °C
3: 100 percent / W-2 Raney Ni / ethanol / 0.5 h / Heating
View Scheme
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
1: 82 percent / Et3N / ethyl acetate / 12 h / 65 °C
2: 19 percent / Rh2(OAc)4 / CH2Cl2 / Ambient temperature
View Scheme
参考文献
West; Naidu
Journal of the American Chemical Society, 1993 , vol. 115, # 3 p. 1177 - 1178
