N-[[(5S)-3-[3-氟-4-[4-(2-羟基乙酰基)-1-哌嗪基]苯基]-2-氧代-5-噁唑烷基]甲基]-乙酰胺合成路线 （共 8 条）
反应条件
hydrogen; palladium on activated charcoal in methanol; dichloromethane
P=760 Torr;
参考文献
Narina, Srinivasarao V.; Sudalai, Arumugam
Tetrahedron Letters, 2006 , vol. 47, # 38 p. 6799 - 6802
反应条件
1: (S)-N-[[3-[3-fluoro-4-[N-1-(4-carbobenzoxy)piperazinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide With methanol; palladium on activated charcoal in ethyl acetate
T=20°C;
2: 2-(phenylmethoxy)acetyl chloride With triethylamine in dichloromethane
T=0 - 20°C;
3: With hydrogen; palladium on activated charcoal in methanol
Further stages.;
参考文献
Guangyu, Xu; Yi, Zhou; Chunhao, Yang; Yuyuan, Xie
Heteroatom Chemistry, 2008 , vol. 19, # 3 p. 316 - 319
反应条件
1: 95 percent / n-BuLi / tetrahydrofuran / 2 h / 0 - 60 °C
2: hydrogen / 10percent Pd/C / CH2Cl2; methanol / 760 Torr / Ambient temperature
3: TEA / CH2Cl2 / 0 °C
4: hydrogen / 10percent Pd/C / CH2Cl2; methanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Schaus, Scott E.; Jacobsen, Eric N.
Tetrahedron Letters, 1996 , vol. 37, # 44 p. 7937 - 7940
反应条件
1: 89 percent / K2CO3 / methanol / 2 h / Ambient temperature
2: 95 percent / n-BuLi / tetrahydrofuran / 2 h / 0 - 60 °C
3: hydrogen / 10percent Pd/C / CH2Cl2; methanol / 760 Torr / Ambient temperature
4: TEA / CH2Cl2 / 0 °C
5: hydrogen / 10percent Pd/C / CH2Cl2; methanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Schaus, Scott E.; Jacobsen, Eric N.
Tetrahedron Letters, 1996 , vol. 37, # 44 p. 7937 - 7940
反应条件
1: Et3N
2: NaN3 / dimethylsulfoxide / 80 °C
3: Ambient temperature
View Scheme
参考文献
Lohray, Braj B.; Baskaran, Sundarababu; Rao, B. Srinivasa; Reddy, B. Yadi; Rao, I. Nageswara
Tetrahedron Letters, 1999 , vol. 40, # 26 p. 4855 - 4856
反应条件
1: lead tetraacetate (LTA) / tetrahydrofuran / 0 °C
2: NaBH4 / methanol / 0 °C
3: Et3N
4: NaN3 / dimethylsulfoxide / 80 °C
5: Ambient temperature
View Scheme
参考文献
Lohray, Braj B.; Baskaran, Sundarababu; Rao, B. Srinivasa; Reddy, B. Yadi; Rao, I. Nageswara
Tetrahedron Letters, 1999 , vol. 40, # 26 p. 4855 - 4856
反应条件
1: 2N HCl / Ambient temperature
2: lead tetraacetate (LTA) / tetrahydrofuran / 0 °C
3: NaBH4 / methanol / 0 °C
4: Et3N
5: NaN3 / dimethylsulfoxide / 80 °C
6: Ambient temperature
View Scheme
参考文献
Lohray, Braj B.; Baskaran, Sundarababu; Rao, B. Srinivasa; Reddy, B. Yadi; Rao, I. Nageswara
Tetrahedron Letters, 1999 , vol. 40, # 26 p. 4855 - 4856
反应条件
Ambient temperature;
参考文献
Lohray, Braj B.; Baskaran, Sundarababu; Rao, B. Srinivasa; Reddy, B. Yadi; Rao, I. Nageswara
Tetrahedron Letters, 1999 , vol. 40, # 26 p. 4855 - 4856
