4-二甲氧基甲基嘧啶-2-胺合成路线 （共 7 条）
反应条件
1: methylglyoxylate methanol hemiacetal; N,N-dimethyl-formamide dimethyl acetal in N,N-dimethyl-formamide T=110°C; 15 h; 2: 1-methylguanidine hydrochloride With sodium hydroxide in water; N,N-dimethyl-formamide T=110°C; 36 h;
参考文献
Naik, Nilesh H.; Sikder, Arun K.; Kusurkar, Radhika S.
Tetrahedron Letters, 2013 , vol. 54, # 28 p. 3715 - 3717
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 22 p. 3111 - 3116
反应条件
sodium hydroxide in water
参考文献
Adams; Jerry L.; Boehm; Jeffrey C.
Patent: US5593991 A1, 1997 ;
反应条件
hydrogenchloride in water T=48°C; 14 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: EP1229035 A1, 2002 ;
Location in patent: Page 25 ;
Title/Abstract Full Text Show Details
SMITHKLINE BEECHAM CORPORATION
Patent: EP1227091 A2, 2002 ;
Location in patent: Page 25 ;
反应条件
1: 18 h / 100 °C 2: aq. NaOH View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 22 p. 3111 - 3116
反应条件
hydrogenchloride; sodium tetrahydroborate; NaOH in tetrahydrofuran; methanol; water; 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran
参考文献
Charron, Catherine Elisabeth; Fenton, Robert; Crowe, Scott; Ito, Kazuhiro; Strong, Peter; Rapeport, William Garth; Ray, Keith
Patent: US2012/244120 A1, 2012 ;
反应条件
hydrogenchloride in water T=48°C; 14 h;
参考文献
SmithKline Beecham Corporation
Patent: EP1227092 A2, 2002 ;
Location in patent: Page 25 ;
