2,3,4,5-四氟苯甲酸合成路线 （共 13 条）
反应条件
1: aq. HNO3, H2SO4 2: Sn, aq. HCl 3: Br2 / Heating 4: aq. H2SO4 / Heating 5: dimethylformamide / Heating 6: aq. H2O2, (CF3CO)2O / CH2Cl2 / Heating 7: H2SO4 8: aq. H2SO4 View Scheme
参考文献
Tetrahedron, , vol. 23, p. 4719 - 4727
反应条件
1: Sn, aq. HCl 2: Br2 / Heating 3: aq. H2SO4 / Heating 4: dimethylformamide / Heating 5: aq. H2O2, (CF3CO)2O / CH2Cl2 / Heating 6: H2SO4 7: aq. H2SO4 View Scheme
参考文献
Tetrahedron, , vol. 23, p. 4719 - 4727
反应条件
1: Br2 / Heating 2: aq. H2SO4 / Heating 3: dimethylformamide / Heating 4: aq. H2O2, (CF3CO)2O / CH2Cl2 / Heating 5: H2SO4 6: aq. H2SO4 View Scheme
参考文献
Tetrahedron, , vol. 23, p. 4719 - 4727
反应条件
1: dimethylformamide / Heating 2: aq. H2O2, (CF3CO)2O / CH2Cl2 / Heating 3: H2SO4 4: aq. H2SO4 View Scheme
参考文献
Tetrahedron, , vol. 23, p. 4719 - 4727
反应条件
1: aq. H2O2, (CF3CO)2O / CH2Cl2 / Heating 2: H2SO4 3: aq. H2SO4 View Scheme
参考文献
Tetrahedron, , vol. 23, p. 4719 - 4727
反应条件
1: aq. H2SO4 / Heating 2: dimethylformamide / Heating 3: aq. H2O2, (CF3CO)2O / CH2Cl2 / Heating 4: H2SO4 5: aq. H2SO4 View Scheme
参考文献
Tetrahedron, , vol. 23, p. 4719 - 4727
参考文献
Tetrahedron, , vol. 23, p. 4719 - 4727
反应条件
1: H2SO4 2: aq. H2SO4 View Scheme
参考文献
Tetrahedron, , vol. 23, p. 4719 - 4727
反应条件
1: oxalyl chloride, DMF / CH2Cl2 / 16 h 2: 1.) n-BuLi, dipyridyl / 1.) THF, -30 deg C, 2.) THF, from -78 deg C to -35 deg C, 1 h 3: 95 percent / Ac2O / 3 h / Heating 4: 2-methyl-propan-2-ol / 3.5 h / 45 °C 5: t-BuOK / 6 h / 60 °C 6: 100 percent / H2 / RaNi / tetrahydrofuran; ethanol / 12 h / 1034.3 Torr 7: 100 percent / 6 M HCl / 2 h / Heating View Scheme
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
反应条件
in dichloromethane; N,N-dimethyl-formamide
参考文献
Warner-Lambert Company
Patent: US4822801 A1, 1989 ;
