2,3,4,5-四氟苯甲酸合成路线 （共 13 条）
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane 16 h;
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
反应条件
1: oxalyl chloride, DMF / CH2Cl2 / 16 h 2: 1.) n-BuLi, dipyridyl / 1.) THF, -30 deg C, 2.) THF, from -78 deg C to -35 deg C, 1 h 3: 95 percent / Ac2O / 3 h / Heating 4: 2-methyl-propan-2-ol / 3.5 h / 45 °C 5: t-BuOK / 6 h / 60 °C View Scheme
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
反应条件
1: oxalyl chloride, DMF / CH2Cl2 / 16 h
2: 1.) n-BuLi, dipyridyl / 1.) THF, -30 deg C, 2.) THF, from -78 deg C to -35 deg C, 1 h
3: 95 percent / Ac2O / 3 h / Heating
4: 2-methyl-propan-2-ol / 3.5 h / 45 °C
5: t-BuOK / 6 h / 60 °C
6: 100 percent / H2 / RaNi / tetrahydrofuran; ethanol / 12 h / 1034.3 Torr
View Scheme
参考文献
Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154
