(2S,4R)-2-甲基-四氢-2H-吡喃-4-醇合成路线 （共 3 条）
反应条件
1.1: hydrogen / palladium on activated charcoal / methanol / 1 h / 2068.65 Torr 2.1: sodium methylate; methanol / 20 °C 3.1: pyridine / -35 - 20 °C 4.1: sodium hydride / mineral oil / 0.75 h / 20 °C 4.2: 20 °C 5.1: tri-n-butyl-tin hydride / 2,2'-azo-bisisobutyronitrile / benzene / 0.33 h / Reflux 6.1: sodium methylate; methanol / 5 h / 20 °C 7.1: triphenylphosphine; diethylazodicarboxylate / benzene / 20 °C 8.1: sodium methylate; methanol / 3 h / 20 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; SRINIVASU, Pothukanuri; BENDER, John A.; LOPEZ, Omar D.; CHEN, Qi; RAMPULLA, Richard A.; GUPTA, Samayamunthula Venkata Satya Arun Kumar; MEANWELL, Nicholas A.
Patent: WO2012/21591 A1, 2012 ;
WO 2012/021591 A1
反应条件
1.1: sodium methylate; methanol / 20 °C 2.1: pyridine / -35 - 20 °C 3.1: sodium hydride / mineral oil / 0.75 h / 20 °C 3.2: 20 °C 4.1: tri-n-butyl-tin hydride / 2,2'-azo-bisisobutyronitrile / benzene / 0.33 h / Reflux 5.1: sodium methylate; methanol / 5 h / 20 °C 6.1: triphenylphosphine; diethylazodicarboxylate / benzene / 20 °C 7.1: sodium methylate; methanol / 3 h / 20 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; SRINIVASU, Pothukanuri; BENDER, John A.; LOPEZ, Omar D.; CHEN, Qi; RAMPULLA, Richard A.; GUPTA, Samayamunthula Venkata Satya Arun Kumar; MEANWELL, Nicholas A.
Patent: WO2012/21591 A1, 2012 ;
WO 2012/021591 A1
反应条件
1.1: sodium hydride / mineral oil / 0.75 h / 20 °C 1.2: 20 °C 2.1: tri-n-butyl-tin hydride / 2,2'-azo-bisisobutyronitrile / benzene / 0.33 h / Reflux 3.1: sodium methylate; methanol / 5 h / 20 °C 4.1: triphenylphosphine; diethylazodicarboxylate / benzene / 20 °C 5.1: sodium methylate; methanol / 3 h / 20 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; SRINIVASU, Pothukanuri; BENDER, John A.; LOPEZ, Omar D.; CHEN, Qi; RAMPULLA, Richard A.; GUPTA, Samayamunthula Venkata Satya Arun Kumar; MEANWELL, Nicholas A.
Patent: WO2012/21591 A1, 2012 ;
WO 2012/021591 A1
