反应条件
1: 68 percent / SnCl2*2H2O, concd HCl / propan-2-ol / 1 h / Heating
2: 1.) aq. NaNO2, AcOH, concd HCl, 2.) CuCN / 1.) 3-5 deg C, 1 h, 2.) H2O, CHCl3, a) 5 deg C, 1 h, b) 22 deg C, 1 h, c) reflux, 1 h
3: 69 percent / K2CO3 / acetonitrile / Heating
View Scheme
参考文献
Markley; Tong; Dulworth; Steward; Goralski; Johnston; Wood; Vinogradoff; Bargar
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 427 - 433
