4-氯-3-硝基苯甲酸乙酯合成路线 （共 20 条）
反应条件
1: 84 percent / tetrahydrofuran / 2 h / 40 °C 2: 34 percent / Zn; NiCl2*6H2O / methanol / Heating View Scheme
参考文献
Ates-Alagoz, Zeynep; Buyukbingol, Erdem
Heterocyclic Communications, 2001 , vol. 7, # 5 p. 455 - 460
反应条件
potassium phosphate; tri-tert-butyl phosphine; tris-(dibenzylideneacetone)dipalladium(0) in toluene T=50°C; 22 h;
参考文献
Tetrahedron Letters, , vol. 48, # 3 p. 473 - 476
反应条件
1: tetrahydrofuran / 50 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
3: lithium hydroxide hydrate / tetrahydrofuran / 20 °C
View Scheme
参考文献
Hwang, Jong Yeon; Attia, Ramy R.; Carrillo, Angela K.; Connelly, Michele C.; Guy, R. Kiplin
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1891 - 1895
反应条件
1: 84 percent / dimethylformamide / 80 °C
2: 94 percent / H2 / Pd/C / ethanol / 2068.59 Torr
View Scheme
参考文献
Oezden, Seckin; Atabey, Dilek; Yildiz, Sulhiye; Goeker, Hakan
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1587 - 1597
反应条件
1: 71 percent / dimethylformamide / 80 °C
2: 93 percent / H2 / Pd/C / ethanol / 2068.59 Torr
View Scheme
参考文献
Oezden, Seckin; Atabey, Dilek; Yildiz, Sulhiye; Goeker, Hakan
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1587 - 1597
反应条件
in dimethyl sulfoxide
T=60°C; 5 h;
参考文献
Boehringer Ingelheim (Canada) Ltd.
Patent: US2003/236251 A1, 2003 ;
Location in patent: Page 19-20 ;
反应条件
in tetrahydrofuran
T=40°C; 2 h;
参考文献
Ates-Alagoz, Zeynep; Buyukbingol, Erdem
Heterocyclic Communications, 2001 , vol. 7, # 5 p. 455 - 460
反应条件
1: THF; KBH4; LiCl
2: thionyl chloride; chloroform
View Scheme
参考文献
McKay et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 4328,4330,4333
反应条件
1.1: triethylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 90 °C / Inert atmosphere
2.1: sodium dithionite / ethanol; dimethyl sulfoxide / 2.5 h / 90 °C / Inert atmosphere
3.1: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 1 h / 30 °C / Inert atmosphere
3.2: 0 °C / pH 4 / Inert atmosphere
View Scheme
参考文献
Oda, Shinichi; Shimizu, Hideki; Aoyama, Yasunori; Ueki, Tatsuo; Shimizu, Sumio; Osato, Hiroshi; Takeuchi, Yoshiyuki
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 96 - 101
反应条件
1: 98 percent / dimethylsulfoxide / 6 h / 70 °C
2: H2 / 20 percent Pd(OH)2/C / methanol / 24 h / 760 Torr
View Scheme
参考文献
Beaulieu, Pierre L.; Hache, Bruno; Von Moos, Elisabeth
Synthesis, 2003 , # 11 p. 1683 - 1692
