6,7-二氢噻唑并[5,4-c]吡啶-5(4H)-羧酸叔丁酯合成路线 （共 5 条）
反应条件
1: 5-Ethoxycarbonyl-4,5,6,7-tetrahydrothiazolo[5,4-c]-pyridine With sodium hydroxide; water Heating / reflux; 2: di-tert-butyl dicarbonate T=0 - 20°C; 3: With hydrogenchloride in water pH=1 - 2;
参考文献
EP1577301 A1, ;
Page/Page column 80-81 ;
反应条件
hydrogenchloride; sodium hydroxide; sodium hydrogencarbonate in dichloromethane
反应条件
1: aq. NaOH / 2 h / 110 °C 2: 21.1 g / methanol; H2O / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 21 p. 5167 - 5182
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 11 p. 2935 - 2939
反应条件
1: 51 percent / molecular sieves 4 Angstroem / ethanol 2: aq. NaOH View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 11 p. 2935 - 2939
