反应条件
1: LiAlH4 / diethyl ether / 0.5 h / 25 °C
2: 99 percent / imidazole / dimethylformamide / 18 h / 25 °C
3: 80 percent / p-TsOH*H2O / methanol / 0.83 h / 25 °C
4: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 30 min, 2.) 25 deg C, 30 min
5: BF3*Et2O / CH2Cl2 / 1.) -86 deg C, 15 min; -86 to -70 deg C, 45 min, 2.) 0 deg C, 1 h
6: 100 percent / i-Pr2NEt / CH2Cl2 / 18 h / 25 °C
7: 1.) 9-BBN, 2.) 3 N aq. NaOH, 31percent aq. H2O2 / 1.) THF, 25 deg C, 17 h, 2.) 25 deg C, 7 h
8: 87 percent / pyridine, n-Bu3P / 45 h / 25 °C
9: 100 percent / 80percent m-CPBA, NaHCO3 / CH2Cl2 / 1.5 h / 25 °C
10: n-BuLi / diethyl ether; hexane / 1.) -78 deg C, 30 min, 2.) 25 deg C, 4.5 h
11: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 30 min, 2.) 5 deg C, 30 min
12: 51 percent / SmI2 / tetrahydrofuran; methanol / 0.33 h / -78 °C
13: 91 percent / K2CO3 / methanol / 2.5 h / 60 °C
14: 79 percent / TMSBr / CH2Cl2 / 1.) -30 deg C, 5 min, 2.) 3 deg C, 30 min
15: 100 percent / TBAF / tetrahydrofuran / 5.5 h / 25 °C
16: 80 percent / Dess-Martin periodinane / CH2Cl2 / 2 h / 25 °C
17: 86 percent / molecular sieves 4 Angstroem / toluene / 1.) -78 deg C, 2 h, 2.) -78 deg C to r.t.
18: 85 percent / t-BuOOH / VO(acac)2 / CH2Cl2 / 7 h / 25 °C
19: 92 percent / Et3N, DMAP / CH2Cl2 / 2.5 h / 3 °C
20: 90 percent / LiEt3BH / tetrahydrofuran / 1 h / 3 °C
21: 95 percent / PDC, molecular sieves 3 Angstroem / CH2Cl2 / 1 h / 25 °C
22: Et3N / CH2Cl2 / 1 h / 3 °C
23: TiCl4 / CH2Cl2 / 3 h / -78 - -15 °C
24: aq. HF / acetonitrile / 2 h / Ambient temperature
25: 72 percent / O2, CuCl, H2O / PdCl2 / dimethylformamide / 15 h / 25 °C
26: 41 percent / TESOTf, 2,6-lutidine / CH2Cl2 / 4 h / 25 °C
View Scheme
参考文献
Oikawa, Masato; Ueno, Tohru; Oikawa, Hideaki; Ichihara, Akitami
Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5048 - 5068
