n-butyllithium; ammonium chloride in tetrahydrofuran

1: 2-iodo-propane; 2-hydroxy-5-bromo-benzoic aldehyde With sodium hydride in N,N-dimethyl-formamide T=20°C; 24 h; 2: methylidene triphenyl phosphorane in tetrahydrofuran T=-78 - 20°C; 1 h;

in tetrahydrofuran T=20°C; 24 h;

1: 96 percent / K2CO3; Cs2CO3 / dimethylformamide / 24 h / 20 °C 2: 91 percent / tetrahydrofuran / 24 h / 20 °C View Scheme

1: 4-bromo-1-isopropoxy-2-vinylbenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-78 - 20°C; Inert atmosphere;