N-叔丁氧基羰基-1,4-TRANS-二氨基甲基环己烷合成路线 （共 7 条）
反应条件
ammonium acetate; sodium cyanoborohydride in methanol T=20°C; 18 h;
参考文献
Jubian, Vrej; Packiarajan, Mathivanan; Reinhard, Emily
Patent: US2007/213376 A1, 2007 ;
Location in patent: Page/Page column 13 ;
US 20070213376 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 6 h;
参考文献
Kanuma, Kosuke; Omodera, Katsunori; Nishiguchi, Mariko; Funakoshi, Takeo; Chaki, Shigeyuki; Semple, Graeme; Tran, Thuy-Anh; Kramer, Bryan; Hsu, Debbie; Casper, Martin; Thomsen, Bill; Beeley, Nigel; Sekiguchi, Yoshinori
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2565 - 2569
反应条件
1: NaN3 / dimethylformamide / 4 h / 50 °C 2: 91 percent / lithium aluminum hydride / tetrahydrofuran / 6 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 10 p. 2565 - 2569
反应条件
1: 67 percent / aq. NaOH / 2-methyl-propan-2-ol / 18 h / 20 °C 2: Et3N / CH2Cl2 / 0.83 h / 0 °C 3: NaBH4 / tetrahydrofuran; methanol / 3 h / 4 °C 4: pyridine / 15 h / 4 - 20 °C 5: NaN3 / dimethylformamide / 4 h / 50 °C 6: 91 percent / lithium aluminum hydride / tetrahydrofuran / 6 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 10 p. 2565 - 2569
反应条件
1: 67 percent / aq. NaOH / 2-methyl-propan-2-ol / 18 h / 20 °C 2: Et3N / CH2Cl2 / 0.83 h / 0 °C 3: NaBH4 / tetrahydrofuran; methanol / 3 h / 4 °C 4: pyridine / 15 h / 4 - 20 °C 5: NaN3 / dimethylformamide / 4 h / 50 °C 6: 91 percent / lithium aluminum hydride / tetrahydrofuran / 6 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 10 p. 2565 - 2569
反应条件
1: Et3N / CH2Cl2 / 0.83 h / 0 °C 2: NaBH4 / tetrahydrofuran; methanol / 3 h / 4 °C 3: pyridine / 15 h / 4 - 20 °C 4: NaN3 / dimethylformamide / 4 h / 50 °C 5: 91 percent / lithium aluminum hydride / tetrahydrofuran / 6 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 10 p. 2565 - 2569
反应条件
1: pyridine / 15 h / 4 - 20 °C 2: NaN3 / dimethylformamide / 4 h / 50 °C 3: 91 percent / lithium aluminum hydride / tetrahydrofuran / 6 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 10 p. 2565 - 2569
