4,5-二氟-2-硝基乙酰苯胺合成路线 （共 6 条）
反应条件
sulfuric acid; nitric acid T=0 - 16°C; 1.5 h;
参考文献
Kotovskaya; Charushin; Chupakhin; Kozhevnikova
Russian Journal of Organic Chemistry, 1998 , vol. 34, # 3 p. 369 - 374
反应条件
1: 87 percent / 0.5 h / 0 - 5 °C 2: 93 percent / H2SO4, HNO3 / 1.5 h / 0 - 16 °C View Scheme
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
反应条件
hydrogenchloride in ethanol 3 h; Heating;
参考文献
El-Abadelah, Mustafa M.; Nazer, Musa Z.; El-Abadla, Naser S.; Meier, Herbert
Heterocycles, 1995 , vol. 41, # 10 p. 2203 - 2220
反应条件
1: 70 percent / HCl / ethanol / 2 h / Heating 2: 42 percent / SnCl2.2H2O / HCl / 2 h / 50 - 60 °C View Scheme
参考文献
Uchida; Morita; Chihiro; Kanbe; Yamasaki; Yabuuchi; Nakagawa
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 6 p. 1517 - 1523
反应条件
1: 70 percent / HCl / ethanol / 2 h / Heating 2: 57 percent / sodium metal / 3 h / Heating View Scheme
参考文献
Uchida; Morita; Chihiro; Kanbe; Yamasaki; Yabuuchi; Nakagawa
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 6 p. 1517 - 1523
反应条件
1: 87 percent / HCl / ethanol / 2 h / Heating 2: 1.) HCl, H2O, NaNO2, 2.) NaN3, AcONa / 1.) 0 deg C, 15 min, 2.) H2O 3: 57 percent / H2O / 2 h / Heating View Scheme
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
