4-硝基苯基 N-(苄氧羰基)-L-色氨酸酯合成路线 （共 6 条）
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran T=20°C; 4 h;
参考文献
Deng, Guanghui; Liu, Zhiguo; Ye, Fei; Luo, Xiaomin; Zhu, Weiliang; Shen, Xu; Liu, Hong; Jiang, Hualiang
European Journal of Medicinal Chemistry, 2008 , vol. 43, # 12 p. 2699 - 2716
反应条件
triethylamine in tetrahydrofuran; water T=20°C;
参考文献
Deng, Guanghui; Liu, Zhiguo; Ye, Fei; Luo, Xiaomin; Zhu, Weiliang; Shen, Xu; Liu, Hong; Jiang, Hualiang
European Journal of Medicinal Chemistry, 2008 , vol. 43, # 12 p. 2699 - 2716
反应条件
N-hexadecyl-N,N,N-trimethylammonium bromide; Dec-L-His in acetonitrile T=25°C; 0.02M phosphate buffer, pH=7.3; other catalysts; Rate constant;
参考文献
Tian, Jiaher; Tan, Jue; Schowen, K. Barbara; Schowen, Richard L.
Canadian Journal of Chemistry, 1999 , vol. 77, # 5-6 p. 781 - 786
反应条件
γ-cyclodextrin in acetonitrile T=25°C; pH=9.5; Kinetics; Further Variations:Reagents;
参考文献
Goto, Koichi; Nakashima, Kentaro; Tanoue, Osamu; Nukushina, Satoshi; Toudo, Isao; Imamura, Chikara; Ihara, Yasuji; Matsumoto, Yoko; Ueoka, Ryuichi
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 9 p. 1283 - 1285
反应条件
pyridine; sodium hydroxide 0.5 h;
参考文献
Bodanszky; Tolle; Seto; Sawyer
Journal of medicinal chemistry, 1980 , vol. 23, # 11 p. 1259 - 1261
反应条件
1: 95 percent / aq. NaOH, pyridine / 0.5 h
2: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C
3: NH3 / tetrahydrofuran / 0.5 h / -15 °C
4: H2 / 10percent Pd/C / aq. ethanol / 3 h
View Scheme
参考文献
Bodanszky; Tolle; Seto; Sawyer
Journal of medicinal chemistry, 1980 , vol. 23, # 11 p. 1259 - 1261
