4-氯-3-羟基苯甲酸甲酯合成路线 （共 4 条）
反应条件
dihydrogen peroxide in dichloromethane; water T=20°C;
参考文献
XenoPort, Inc.
Patent: US2010/267676 A1, 2010 ;
Location in patent: Page/Page column 54 ;
US 20100267676 A1
反应条件
hydrogenchloride 1 h; Heating;
参考文献
Yamawaki; Bukovac; Sunami
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 11 p. 2365 - 2369
反应条件
1: 2-chloro-5-(trifluoromethyl)-phenol With sulfuric acid T=100°C; 1 h; 2: methanol 3 h; Reflux;
参考文献
WYETH
Patent: WO2005/12291 A1, 2005 ;
Location in patent: Page/Page column 66 ;
WO 2005/012291 A1
反应条件
in methanol hydrochloric acid
