N-乙酰基-S-甲基-L-半胱氨酸合成路线 （共 8 条）
反应条件
1: With sodium methylate in methanol T=20 - 30°C; 1 h; Heating / reflux; 2: With hydrogenchloride in methanol; water T=50 - 60°C;
参考文献
ZAMBON GROUP S.p.A.
Patent: EP1053225 B1, 2004 ;
Location in patent: Page 6 ;
反应条件
sodium hydroxide T=0 - 20°C; 2.5 h;
参考文献
Parry; Li; Gomez
Journal of the American Chemical Society, 1992 , vol. 114, # 15 p. 5946 - 5959
反应条件
acetic anhydride in sodium hydroxide
参考文献
Mitsubishi Chemical Industries, Limited
Patent: US4440788 A1, 1984 ;
反应条件
zinc in acetonitrile 2 h; Ambient temperature;
参考文献
Chowdhury, Shantanu; Roy, Sujit
Tetrahedron Letters, 1997 , vol. 38, # 12 p. 2149 - 2152
反应条件
ammonia in methanol; ethyl acetate Alkylation;
参考文献
Perrey, David A.; Scannell, Michael P.; Narla, Rama Krishna; Uckun, Fatih M.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 6 p. 551 - 552
反应条件
T=100 - 110°C; unter vermindertem Druck;
参考文献
Blackburn; Consden; Phillips
Biochemical Journal, 1944 , vol. 38, p. 26
参考文献
Blackburn; Consden; Phillips
Biochemical Journal, 1944 , vol. 38, p. 26
反应条件
1: With hydrogen bromide in water T=60 - 105°C; 4 h; 2: With sodium hydroxide in water T=30 - 70°C;
参考文献
ZAMBON GROUP S.p.A.
Patent: EP1053225 B1, 2004 ;
Location in patent: Page 6 ;
