2-[2-(2-叠氮乙氧基)乙氧基]乙胺合成路线 （共 9 条）
反应条件
hydrogenchloride; triphenylphosphine in tetrahydrofuran; diethyl ether T=20°C; 12 h;
参考文献
Klein, Emmanuel; DeBonis, Salvatore; Thiede, Bernd; Skoufias, Dimitrios A.; Kozielski, Frank; Lebeau, Luc
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 19 p. 6474 - 6488
反应条件
sodium azide; CuSO4‵5H2O; trifluoromethylsulfonic anhydride; potassium carbonate in methanol; dichloromethane; water T=20°C;
参考文献
Li, Ying; Schaffer, Paul; Perrin, David M.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 23 p. 6313 - 6316
反应条件
trifluoroacetic acid in dichloromethane 2.5 h;
参考文献
Lu, Yan; Gervay-Hague, Jacquelyn
Carbohydrate Research, 2007 , vol. 342, # 12-13 p. 1636 - 1650
反应条件
1: 99 percent / NaN3 / NaI / acetonitrile / 48 h / Heating 2: 77 percent / PPh3; aq. HCl / diethyl ether; tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 6 p. 1499 - 1503
反应条件
1: potassium hydroxide / dichloromethane / 3 h / 0 °C 2: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 80 °C 3: triphenylphosphine; hydrogenchloride / tetrahydrofuran; diethyl ether / 20 - 22 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 45 p. 18809 - 18815
反应条件
sodium azide in water T=80°C; 15 h;
参考文献
Zheng, Hong; Wang, Fang; Wang, Qin; Gao, Jianmin
Journal of the American Chemical Society, 2011 , vol. 133, # 39 p. 15280 - 15283
反应条件
1: 1.16 g / TfN3 / H2O; methanol; CH2Cl2 / 18 h / 20 °C 2: 56 percent / TFA / CH2Cl2 / 2.5 h View Scheme
参考文献
Carbohydrate Research, , vol. 342, # 12-13 p. 1636 - 1650
反应条件
1: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 80 °C 2: triphenylphosphine; hydrogenchloride / tetrahydrofuran; diethyl ether / 20 - 22 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 45 p. 18809 - 18815
反应条件
1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0 °C 2: tri-iso-propylsilane; trifluoroacetic acid / water / 1 h 3: sodium azide / water / 15 h / 80 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 133, # 39 p. 15280 - 15283
