6-氰基-3,4-二氢-2(1H)-异喹啉羧酸-1,1-二甲基乙酯合成路线 （共 6 条）
反应条件
triethylamine in dichloromethane T=20°C; 1 h;
参考文献
ACS Medicinal Chemistry Letters, , vol. 2, # 6 p. 444 - 449
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=80°C; 0.75 h; Yield given;
参考文献
Synthetic Communications, , vol. 25, # 20 p. 3255 - 3261
反应条件
1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 1 h / 130 °C / Irradiation with microwave 2: triethylamine / dichloromethane / 1 h / 25 °C View Scheme
参考文献
WO2010/146105 A1, ;
WO 2010/146105 A1
反应条件
1: 61 percent / Et3N / tetrahydrofuran; H2O / Ambient temperature 2: Et3N / CH2Cl2 / 0 °C 3: palladium tetrakistriphenylphosphine / dimethylformamide / 0.75 h / 80 °C View Scheme
参考文献
Synthetic Communications, , vol. 25, # 20 p. 3255 - 3261
反应条件
1: 61 percent / Et3N / tetrahydrofuran; H2O / Ambient temperature 2: Et3N / CH2Cl2 / 0 °C 3: palladium tetrakistriphenylphosphine / dimethylformamide / 0.75 h / 80 °C View Scheme
参考文献
Synthetic Communications, , vol. 25, # 20 p. 3255 - 3261
反应条件
1: Et3N / CH2Cl2 / 0 °C 2: palladium tetrakistriphenylphosphine / dimethylformamide / 0.75 h / 80 °C View Scheme
参考文献
Synthetic Communications, , vol. 25, # 20 p. 3255 - 3261
