1-甲基-beta-咔啉-3-羧酸甲酯合成路线 （共 15 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Sung; Koike; Nikaido; et al.
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 5 p. 1872 - 1877
反应条件
potassium permanganate in N,N-dimethyl-formamide
T=20°C; 14 h;
参考文献
Li, Chunyu; Zhang, Xiaoyi; Zhao, Ming; Wang, Yuji; Wu, Jianhui; Liu, Jiawang; Zheng, Meiqing; Peng, Shiqi
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 11 p. 5598 - 5608
反应条件
sulfur in xylene
4.5 h; Heating;
参考文献
Razmilic; Castillo; Lopez
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 3 p. 595 - 596
反应条件
Sodium hydride in N,N-dimethyl-formamide
T=28°C; 0.5 h;
参考文献
Brahmbhatt, Keyur G.; Ahmed, Nafees; Sabde, Sudeep; Mitra, Debashis; Singh, Inder Pal; Bhutani, Kamlesh K.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 15 p. 4416 - 4419
反应条件
oxygen; 1,8-diazabicyclo[5.4.0]undec-7-ene in dimethyl sulfoxide
T=20°C; 6 h;
参考文献
Dong, Jing; Shi, Xiao-Xin; Yan, Jing-Jing; Xing, Jing; Zhang, Qiang; Xiao, Sen
European Journal of Organic Chemistry, 2010 , # 36 p. 6987 - 6992
反应条件
1: SOCl2
2: S / xylene; dioxane
View Scheme
参考文献
Yu, Xiaolin; Lin, Wei; Li, Jingyun; Yang, Ming
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3127 - 3130
反应条件
sulfur in xylene
96 h; Heating;
参考文献
Zhao, Ming; Bi, Lanrong; Wang, Wei; Wang, Chao; Baudy-Floc'h, Michele; Ju, Jingfang; Peng, Shiqi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 20 p. 6998 - 7010
反应条件
1: H(+)
2: SOCl2
3: S / xylene; dioxane
View Scheme
参考文献
Yu, Xiaolin; Lin, Wei; Li, Jingyun; Yang, Ming
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3127 - 3130
反应条件
1: SOCl2
2: 31 percent / sulfuric acid; ammonia / H2O / 6 h / 20 °C / pH 6 - 7
3: 65 percent / KMnO4 / dimethylformamide / 14 h / 20 °C
View Scheme
参考文献
Zhao, Ming; Bi, Lanrong; Wang, Wei; Wang, Chao; Baudy-Floc'h, Michele; Ju, Jingfang; Peng, Shiqi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 20 p. 6998 - 7010
反应条件
silica gel; trichlorophosphate
Bischler-Napieralski condensation; 0.15 h; microwave irradiation;
参考文献
Pal, Bikash; Jaisankar, Parasuraman; Giri, Venkatachalam S.
Synthetic Communications, 2003 , vol. 33, # 13 p. 2339 - 2348
