1-甲基-3-环己烯羧酸合成路线 （共 10 条）
反应条件
triphenylphosphine; bis(acetylacetonato) palladium; triethylaluminum in tetrahydrofuran T=60°C; 6 h;
参考文献
Baibulatova, N. Z.; Kunakova, R. V.; Lomakina, S. I.; Dzhemilev, U. M.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, p. 39 - 44
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 1 p. 46 - 52
反应条件
nickel; ethyl acetate T=180°C; P=73550.8 Torr; Hydrogenation;
参考文献
Baumgarten; Bower; Okamoto
Journal of the American Chemical Society, 1957 , vol. 79, p. 3145,3148
反应条件
1: Raney nickel; ethyl acetate / 180 °C / 73550.8 Torr / Hydrogenation 2: lithium alanate; diethyl ether View Scheme
参考文献
Jacquier; Christol
Bulletin de la Societe Chimique de France, 1957 , p. 600,606
反应条件
1: (+-)-3-Cyclohexene-1-carboxylic acid With n-butyllithium; HMPA; diisopropylamine in tetrahydrofuran; hexane
T=-20 - 20°C; Inert atmosphere;
2: methyl iodide in tetrahydrofuran; hexane
T=-25 - 20°C;
参考文献
Hosoya, Masahiro; Otani, Yuko; Kawahata, Masatoshi; Yamaguchi, Kentaro; Ohwada, Tomohiko
Journal of the American Chemical Society, 2010 , vol. 132, # 42 p. 14780 - 14789
反应条件
sodium hydroxide in water
5 h; Heating;
参考文献
House, Herbert O.; Haack, John L.; McDaniel, William C.; VanDerveer, Don
Journal of Organic Chemistry, 1983 , vol. 48, # 10 p. 1643 - 1654
反应条件
n-butyllithium in tetrahydrofuran
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: US2012/171245 A1, 2012 ;
反应条件
toluene; 1,2,3-benzenetriol
T=150°C;
参考文献
Petrow; Ssopow
Zhurnal Obshchei Khimii, 1948 , vol. 18, p. 1783
Chem.Abstr., 1949 , p. 3373
Full Text Show Details
Baumgarten; Bower; Okamoto
Journal of the American Chemical Society, 1957 , vol. 79, p. 3145,3148
反应条件
dipyridinium dichromate in N,N-dimethyl-formamide
参考文献
Corey,E.J.; Schmidt,G.
Tetrahedron Letters, 1979 , p. 399 - 402
反应条件
1: Na / ethane-1,2-diol
2: Na
3: aq. H2SO4 / dioxane
4: AgNO3, aq. NaOH / dioxane
View Scheme
参考文献
Wenkert,E. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 2092 - 2095
反应条件
1: aq. H2SO4 / dioxane
2: AgNO3, aq. NaOH / dioxane
View Scheme
参考文献
Wenkert,E. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 2092 - 2095
