1-(5-苯基噻吩-2-基)乙酮合成路线 （共 21 条）
反应条件
1: phenyl-magnesium bromide With bismuth(III) chloride 2: 1-(5-iodothiophen-2-yl)ethanone With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=90°C; 1 h; Inert atmosphere;
参考文献
Rao, Maddali L. N.; Banerjee, Debasis; Dhanorkar, Ritesh J.
Synlett, 2011 , # 9 p. 1324 - 1330
反应条件
1: β-chloro cinnamaldehyde With sodium sulfide nonahydrate in N,N-dimethyl-formamide T=60°C; 2 h; 2: chloroacetone in N,N-dimethyl-formamide T=60°C; 3 h; 3: With potassium carbonate in water; N,N-dimethyl-formamide T=60°C; 0.166667 h;
参考文献
Herbivo, Cyril; Comel, Alain; Kirsch; Raposo, M. Manuela M.
Tetrahedron, 2009 , vol. 65, # 10 p. 2079 - 2086
反应条件
(C2H5OC(O)C6H2(OP(C6H5)2)2)Pd(OCOCF3); potassium acetate T=130°C; 18 h; Inert atmosphereSealed tube; Reagent/catalyst; regioselective reaction;
参考文献
Churruca, Fatima; Hernandez, Susana; Perea, Maria; SanMartin, Raul; Dominguez, Esther
Chemical Communications, 2013 , vol. 49, # 14 p. 1413 - 1415
反应条件
1: Br2; CH3COONa; H2O 2: 88 percent / K2CO3; H2O / 1,2-dimethoxy-ethane View Scheme
参考文献
Synlett, , # 10 p. 1621 - 1623
反应条件
palladium diacetate; acetic acid; benzene 17 h; Heating; Yield given. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 50, # 25 p. 5272 - 5275
反应条件
palladium diacetate; acetic acid 17 h; Heating; Yield given. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 50, # 25 p. 5272 - 5275
反应条件
titanium tetrachloride; benzene
参考文献
Justus Liebigs Annalen der Chemie, , vol. 543, p. 119,126
参考文献
Antonioletti, Roberto; Auria, Maurizio D'; Onofrio, Franco D'; Piancatelli, Giovanni; Scettri, Arrigo
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1755 - 1758
参考文献
Justus Liebigs Annalen der Chemie, , vol. 543, p. 119,126
Acta Chemica Scandinavica (1947-1973), , vol. 26, p. 1853,1858
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; triethylamine in ethanol Suzuki-Miyaura cross-coupling; 10 h; Heating; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 68, # 11 p. 4302 - 4314
