1: With toluene-4-sulfonic acid in toluene 5.46667 h; Heating / reflux; 2: With sodium hydroxide; water in toluene T=60°C; 9 h; 3: With hydrogenchloride in water T=2 - 14°C; 14.5 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/34133 A1, 2009 ;
Location in patent: Page/Page column 18 ;
WO 2009/034133 A1