4-甲氧基-吡啶-2-乙酸甲酯合成路线 （共 9 条）
参考文献
Pfizer Inc.
Patent: US4562197 A1, 1985 ;
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
1: 83.9 percent / H2SO4; HNO3 / 2 h / 110 - 115 °C 2: 79.1 percent / methanol / 1.5 h / 20 °C 3: 0.5 h / 110 - 120 °C View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
反应条件
1: 79.1 percent / methanol / 1.5 h / 20 °C 2: 0.5 h / 110 - 120 °C View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 98 percent / conc. H2SO4, 65percent HNO3 / 22 h / 95 °C 2: 100 percent / K2CO3 / 12 h / Heating 3: 4 h / 100 °C View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1: 1 mol/l aq. NaOH / methanol / 0.75 h / 20 °C 2: SOCl2 / CH2Cl2 / Heating View Scheme
参考文献
Weidmann, Klaus; Herling, Andreas W.; Lang, Hans-Jochen; Scheunemann, Karl-Heinz; Rippel, Robert; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 438 - 450
反应条件
potassium carbonate in hydrogenchloride
反应条件
1: 2 N aq. NaOH / 2 h / 80 °C
2: SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C
3: 2 N aq. NaOH / ethanol / 2 h / 50 °C
4: 94 percent / 10percent aq. NaOCl, 6 N aq. NaOH / ethyl acetate / 0.5 h
View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
反应条件
1: 2 M NaOH / 1 h / 100 °C
2: 100 percent / SOCl2 / CH2Cl2 / 2 h
View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
