(R)-n-甲基-1,2,3,4-四氢喹啉-3-胺合成路线 （共 5 条）
反应条件
dimethylsulfide borane complex in tetrahydrofuran 30 h; Ambient temperature; Yield given;
参考文献
Romero, Arthur G.; Darlington, William H.; McMillan, Moses W.
Journal of Organic Chemistry, 1997 , vol. 62, # 19 p. 6582 - 6587
反应条件
1: 34 g / NaOH / H2O; tetrahydrofuran / 2 h / 25 °C 2: 22.6 g / Na2CO3, EDC / H2O; CH2Cl2 / 22 h / Ambient temperature 3: 19.58 g / PhI(OCOCF3)2 / trifluoroacetic acid; CH2Cl2 / 1 h / 0 °C 4: BH3*Me2S / tetrahydrofuran / 30 h / Ambient temperature View Scheme
参考文献
Romero, Arthur G.; Darlington, William H.; McMillan, Moses W.
Journal of Organic Chemistry, 1997 , vol. 62, # 19 p. 6582 - 6587
反应条件
1: 22.6 g / Na2CO3, EDC / H2O; CH2Cl2 / 22 h / Ambient temperature 2: 19.58 g / PhI(OCOCF3)2 / trifluoroacetic acid; CH2Cl2 / 1 h / 0 °C 3: BH3*Me2S / tetrahydrofuran / 30 h / Ambient temperature View Scheme
参考文献
Romero, Arthur G.; Darlington, William H.; McMillan, Moses W.
Journal of Organic Chemistry, 1997 , vol. 62, # 19 p. 6582 - 6587
反应条件
1: 19.58 g / PhI(OCOCF3)2 / trifluoroacetic acid; CH2Cl2 / 1 h / 0 °C 2: BH3*Me2S / tetrahydrofuran / 30 h / Ambient temperature View Scheme
参考文献
Romero, Arthur G.; Darlington, William H.; McMillan, Moses W.
Journal of Organic Chemistry, 1997 , vol. 62, # 19 p. 6582 - 6587
反应条件
sodium carbonate; triethylamine in hexane; chloroform
参考文献
Pharmacia and Upjohn Company
Patent: US5652245 A1, 1997 ;
