反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 42 h / 20 °C / Inert atmosphere
2.1: palladium 10 on activated carbon; hydrogen; acetic acid / 19 h / 70 °C
3.1: toluene-4-sulfonic acid / toluene / 13 h / Inert atmosphere; Reflux
4.1: pyridine; thionyl chloride / 0 - 20 °C / Inert atmosphere
5.1: platinum(IV) oxide; hydrogen / methanol / 20 h / 20 °C
6.1: hydrogenchloride / water / 1 h / 80 °C / Inert atmosphere
6.2: pH 9
7.1: acetic acid; zinc / 4 h / Inert atmosphere; Reflux
View Scheme
参考文献
Ida, Yoshihiro; Nemoto, Toru; Hirayama, Shigeto; Fujii, Hideaki; Osa, Yumiko; Imai, Masayuki; Nakamura, Takashi; Kanemasa, Toshiyuki; Kato, Akira; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 2 p. 949 - 961