1,4-diaza-bicyclo[2.2.2]octane; hydrogen; palladium on activated charcoal; ethylenediamine in methanol; ethyl acetate T=20°C; Hydrogenolysis; P=760 Torr; 24 h;

sodium hydroxide

1: aqueous methanol. NaOH 2: aqueous NaOH View Scheme

1: 1.) 4-hydroxy-3-nitrobenzophenone fixed to a polystyrene matrix, 2.) triethylamine / 2.) DMF, 50 min 2: 96 percent / hydrogen / palladium-on-carbon / acetic acid; various solvent(s) / 6 h View Scheme