1-甲基-1,2,3-三氮唑合成路线 （共 14 条）
反应条件
potassium carbonate in tetrahydrofuran T=20°C; 3 h;
参考文献
WO2008/98104 A1, ;
Page/Page column 94 ;
WO 2008/098104 A1
参考文献
WO2006/108591 A1, ;
Page/Page column 117-118 ;
WO 2006/108591 A1
反应条件
tetrabutyl ammonium fluoride in acetonitrile T=80°C; 2 h; other alkyl halide, also with MeOCH2Cl and PhCOCH2Br, var. temp. var. time; Product distribution;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 45, # 7 p. 1140 - 1145
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Organic Letters, , vol. 12, # 20 p. 4632 - 4635
反应条件
T=70 - 90°C; P=3 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 16, # 4 p. 641 - 648
Zhurnal Organicheskoi Khimii, , vol. 16, # 4 p. 730 - 738
反应条件
sodium hydride 1.) acetonitrile, 0 deg C, 24 h, 2.) dichloromethane, a) from -25 to 20 deg C, 1 h, b) 20 deg C, 72 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Acta Chemica Scandinavica, , vol. 44, # 10 p. 1050 - 1057
参考文献
Justus Liebigs Annalen der Chemie, , vol. 593, p. 200 - 207
参考文献
Chemische Berichte, , vol. 43, p. 2222
参考文献
Acta Chemica Scandinavica (1947-1973), , vol. 13, p. 888,890
反应条件
1: 3MeTA With n-butyllithium in tetrahydrofuran T=-78 - -60°C; 0.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=20°C; 1 h;
参考文献
PFIZER LIMITED
Patent: WO2008/135826 A2, 2008 ;
Location in patent: Page/Page column 157; 158 ;
WO 2008/135826 A2
