2-(3-氯丙基)-1,3-二噁戊环合成路线 （共 8 条）
反应条件
toluene-4-sulfonic acid in benzene Heating; Yield given;
参考文献
Tetrahedron, , vol. 54, # 24 p. 6661 - 6676
反应条件
in ethanol; water T=95°C; 1 h;
参考文献
BIOVITRUM AB
Patent: WO2005/48916 A2, 2005 ;
Location in patent: Page/Page column 64 ;
WO 2005/048916 A2
反应条件
water; naphthalenyllithium 1) THF, -78 deg C, 7 h, 2) 20 deg C, overnight; Yield given. Multistep reaction;
参考文献
Ramon, Diego J.; Yus, Miguel
Journal of Organic Chemistry, 1991 , vol. 56, # 12 p. 3825 - 3831
反应条件
in ethanol; water T=95°C; 1 h;
参考文献
BIOVITRUM AB
Patent: WO2006/122931 A1, 2006 ;
Location in patent: Page/Page column 18-19 ;
WO 2006/122931 A1
反应条件
(i) Mg, (ii) (heating); Multistep reaction;
参考文献
Forbes,C.P. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1977 , p. 2353 - 2355
反应条件
hydrazine hydrate in methanol
参考文献
American Cyanamid Company
Patent: US5726126 A1, 1998 ;
反应条件
in hexane; dimethyl sulfoxide; ethyl acetate
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US6319946 B1, 2001 ;
US 6319946 B1
反应条件
sodium hydrogencarbonate; sodium iodide in acetone
20 h; Reflux;
参考文献
Studenovsky; Ulbrich; Ibrahimova; Rihova
European Journal of Pharmaceutical Sciences, 2011 , vol. 42, # 1-2 p. 156 - 163
