3-[4-(三氟甲基)苯基]丙醛合成路线 （共 9 条）
反应条件
pyridinium chlorochromate in dichloromethane T=0 - 20°C; 3 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2008/78291 A1, 2008 ;
Location in patent: Page/Page column 52 ;
WO 2008/078291 A1
反应条件
diisobutylaluminium hydride in dichloromethane T=-78°C; 0.166667 h;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2005/42478 A2, 2005 ;
Location in patent: Page/Page column 97-98 ;
WO 2005/042478 A2
反应条件
triethylsilane; trimesitylphosphane; bis(dibenzylideneacetone)-palladium(0) in toluene T=40°C; 3 h; Schlenk techniqueInert atmosphere;
参考文献
Fujihara, Tetsuaki; Cong, Cong; Iwai, Tomohiro; Terao, Jun; Tsuji, Yasushi
Synlett, 2012 , vol. 23, # 16 art. no. ST-2012-U0571-L, p. 2389 - 2392
反应条件
diisobutylaluminium hydride; magnesium sulfate in toluene
参考文献
Chisso Corporation
Patent: US6235355 B1, 2001 ;
反应条件
methylphenylsilane; trimethylacetic anhydride; tris(4-methylphenyl)-phosphine; bis(dibenzylideneacetone)-palladium(0) in toluene T=60°C; 20 h; Schlenk techniqueInert atmosphere;
参考文献
Fujihara, Tetsuaki; Cong, Cong; Terao, Jun; Tsuji, Yasushi
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 17 p. 3420 - 3424
反应条件
1: nickel(II) bromide trihydrate; iron; nickel / 1,2-dibromoethane; tetrabutylammonium bromide / dimethylformamide; pyridine / 7 h / 70 °C / Electrolysis 2: 0.424 g / aqueous HCl / dimethylformamide; pyridine / 0.5 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 5, # 24 p. 4701 - 4703
反应条件
PtCl2{(-)-(2S,4S)-2,4-bis(diphenylphosphino)pentane}; hydrogen; tin(ll) chloride in toluene T=120°C; P=60006 Torr; 1 h; Inert atmosphereAutoclave; Temperature; enantioselective reaction;
参考文献
Organometallics, , vol. 33, # 6 p. 1389 - 1396
反应条件
bis(cyclopentadienyl)titanium dichloride; triethyl amine hydrochloride; zinc in dichloromethane Inert atmosphere; chemoselective reaction;
参考文献
Ashfeld, Brandon L.; Kosal, Andrew D.
Organic Letters, 2010 , vol. 12, # 1 p. 44 - 47
反应条件
in acetonitrile T=25°C; 1 h; Irradiation; Title compound not separated from byproducts.;
参考文献
Journal of Organic Chemistry, , vol. 72, # 25 p. 9464 - 9470
