(alphaR,betaR)-beta-(2,4-二氟苯基)-beta-羟基-alpha-甲基-1H-1,2,4-三唑-1-丁酸合成路线 （共 7 条）
反应条件
sodium hydride in N,N-dimethyl-formamide 1.) 25 deg C, 15 min, 2.) 60 deg C, 3 h; Yield given;
参考文献
J. Uriach and Cia. S.A.
Patent: US5478826 A1, 1995 ;
反应条件
1: With sodium periodate; ruthenium(IV) oxide hydrate; adogene 464; water; acetic acid T=5 - 20°C; 2: With sodium hydroxide; water in isopropyl alcohol pH=4;
参考文献
Xu, Lin; Muller, Marc R.; Yu, Xiong; Zhu, Bao-Quan
Synthetic Communications, 2009 , vol. 39, # 9 p. 1611 - 1625
反应条件
in N,N-dimethyl-formamide T=0 - 60°C;
参考文献
Yu, Luo-Ting; Ho, Meng-Tsung; Chang, Ching-Yao; Yang, Teng-Kuei
Tetrahedron Asymmetry, 2007 , vol. 18, # 8 p. 949 - 962
反应条件
1.1: diethyl zinc / Ni(acac)2 / CH2Cl2; hexane / 0.5 h / 0 °C 1.2: CH2Cl2; hexane / -30 °C 2.1: 71.6 percent / aq. H2O2; LiOH*H2O / tetrahydrofuran / -10 - 0 °C 3.1: 89.3 percent / dimethylformamide / 0 - 60 °C View Scheme
参考文献
Yu, Luo-Ting; Ho, Meng-Tsung; Chang, Ching-Yao; Yang, Teng-Kuei
Tetrahedron Asymmetry, 2007 , vol. 18, # 8 p. 949 - 962
反应条件
1: With sodium hydroxide; water 3 h; Reflux; 2: With hydrogenchloride; water pH=4;
参考文献
Xu, Lin; Muller, Marc R.; Yu, Xiong; Zhu, Bao-Quan
Synthetic Communications, 2009 , vol. 39, # 9 p. 1611 - 1625
反应条件
1: 71.6 percent / aq. H2O2; LiOH*H2O / tetrahydrofuran / -10 - 0 °C 2: 89.3 percent / dimethylformamide / 0 - 60 °C View Scheme
参考文献
Yu, Luo-Ting; Ho, Meng-Tsung; Chang, Ching-Yao; Yang, Teng-Kuei
Tetrahedron Asymmetry, 2007 , vol. 18, # 8 p. 949 - 962
反应条件
1,1'-carbonyldiimidazole in tetrahydrofuran T=60°C; 3 h;
参考文献
Xu, Lin; Muller, Marc R.; Yu, Xiong; Zhu, Bao-Quan
Synthetic Communications, 2009 , vol. 39, # 9 p. 1611 - 1625
