甲基(4-乙酰基-2-甲基苯氧基)乙酸酯合成路线 （共 5 条）
反应条件
caesium carbonate in acetonitrile T=20°C; Williamson reaction; 16 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 9 p. 1517 - 1521
反应条件
1: 87 percent / m-chloroperbenzoic acid; p-TsOH / CH2Cl2 / 6 h / Heating 2: NaOCH3; MeOH 3: 100 percent / DMAP; Et3N / dioxane / 16 h / Heating 4: 47 percent / various solvent(s) / 253 °C 5: 34 percent / NaOCH3; MeOH / 16 h / 70 °C 6: Cs2CO3 / acetonitrile / 16 h / 20 °C 7: 1 N aq. LiOH / tetrahydrofuran View Scheme
参考文献
Sznaidman, Marcos L.; Haffner, Curt D.; Maloney, Patrick R.; Fivush, Adam; Chao, Esther; Goreham, Donna; Sierra, Michael L.; LeGrumelec, Christelle; Xu, H. Eric; Montana, Valerie G.; Lambert, Millard H.; Willson, Timothy M.; Oliver Jr., William R.; Sternbach, Daniel D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 9 p. 1517 - 1521
反应条件
1: meta-chloroperbenzoic acid; p-TsOH / CH2Cl2 / 48 h / Heating 2: MeONa / methanol / 1 h / 20 °C View Scheme
参考文献
Novo Nordisk A/S; High Point Phamaceticals LLC
Patent: US2011/39841 A1, 2011 ;
US 20110039841 A1
反应条件
1: 87 percent / m-chloroperbenzoic acid; p-TsOH / CH2Cl2 / 6 h / Heating 2: NaOCH3; MeOH 3: 100 percent / DMAP; Et3N / dioxane / 16 h / Heating 4: 47 percent / various solvent(s) / 253 °C 5: 34 percent / NaOCH3; MeOH / 16 h / 70 °C 6: Cs2CO3 / acetonitrile / 16 h / 20 °C View Scheme
参考文献
Sznaidman, Marcos L.; Haffner, Curt D.; Maloney, Patrick R.; Fivush, Adam; Chao, Esther; Goreham, Donna; Sierra, Michael L.; LeGrumelec, Christelle; Xu, H. Eric; Montana, Valerie G.; Lambert, Millard H.; Willson, Timothy M.; Oliver Jr., William R.; Sternbach, Daniel D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 9 p. 1517 - 1521
反应条件
1: 87 percent / m-chloroperbenzoic acid; p-TsOH / CH2Cl2 / 6 h / Heating
2: NaOCH3; MeOH
3: 100 percent / DMAP; Et3N / dioxane / 16 h / Heating
4: 47 percent / various solvent(s) / 253 °C
5: 34 percent / NaOCH3; MeOH / 16 h / 70 °C
View Scheme
参考文献
Sznaidman, Marcos L.; Haffner, Curt D.; Maloney, Patrick R.; Fivush, Adam; Chao, Esther; Goreham, Donna; Sierra, Michael L.; LeGrumelec, Christelle; Xu, H. Eric; Montana, Valerie G.; Lambert, Millard H.; Willson, Timothy M.; Oliver Jr., William R.; Sternbach, Daniel D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 9 p. 1517 - 1521
