1-溴-4-((2-甲氧基乙氧基)甲基)苯合成路线 (共 2 条)
反应条件
1: With n-butyllithium in tetrahydrofuran; hexanes
T=-78°C; 0.5 h;
2: With tri-isopropoxy-borane in tetrahydrofuran; hexanes
T=-78 - 20°C; 1.5 h;
3: With hydrogenchloride in tetrahydrofuran; hexanes; water; ethyl acetate
参考文献
Speedel Experimenta AG
Patent: WO2009/50253 A1, 2009 ;
Location in patent: Page/Page column 40 ;
WO 2009/050253 A1
反应条件
1: 1-bromo-4-[(2-methoxyethoxy)methyl]benzene With n-butyllithium in tetrahydrofuran; hexanes
T=-78°C; 0.5 h;
2: tri-isopropoxy-borane in tetrahydrofuran; hexanes
T=-78 - 23°C; 1.5 h;
参考文献
SPEEDEL EXPERIMENTA AG
Patent: WO2009/53452 A1, 2009 ;
Location in patent: Page/Page column 22 ;
WO 2009/053452 A1