7-溴-4,4-二甲基-1-四氢萘酮合成路线 （共 12 条）
反应条件
aluminium trichloride; bromine in dichloromethane T=70°C;
参考文献
Johnson; Klein; Gillett; Wang; Song; Pino; Chandraratna
Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4764 - 4767
Title/Abstract Full Text View citing articles Show Details
Johnson, Alan T.; Wang, Liming; Gillett, Samuel J.; Chandraratna, Roshantha A. S.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 4 p. 573 - 576
反应条件
acetic anhydride; acetic acid in benzene
反应条件
hydrogenchloride; bromine; AlCl3
参考文献
Allergan Sales, Inc.
Patent: US5958954 A1, 1999 ;
US 5958954 A
反应条件
sodium nitrate in concentrated hydrobromic acid; hexane; sulfuric acid; acetic acid
参考文献
Bristol-Myers Squibb Co.
Patent: US5648385 A1, 1997 ;
反应条件
1: 72 percent / AlCl3 / 2.5 h / 90 - 100 °C 2: 65 percent / AlCl3, Br2 / CH2Cl2 / 0.5 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 9 p. 1476 - 1496
反应条件
1: 72 percent / AlCl3 / 2.5 h / 90 - 100 °C 2: 65 percent / AlCl3, Br2 / CH2Cl2 / 0.5 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 9 p. 1476 - 1496
反应条件
1: (PPh3)2PdCl2, CuI, Et2NH / 60 °C 2: K2CO3 / methanol / Ambient temperature 3: 64 percent / (PPh3)2PdCl2, CuI, Et2NH / Ambient temperature 4: 1.) NaN(SiMe3)2 / 1.) THF, -78 deg C, 2.) THF, from 0 deg C to RT 5: 1.) t-BuLi, 2.) ZnCl2, 3.) Pd(PPh3)4 View Scheme
参考文献
Johnson; Klein; Gillett; Wang; Song; Pino; Chandraratna
Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4764 - 4767
反应条件
1: Pd(PPh3)2Cl2, CuI, Et3N / 60 °C 2: K2CO3 / methanol 3: 64 percent / Pd(PPh3)2, CuI, Et3N / 25 °C 4: 77 percent / NaN(SiMe3)2 / tetrahydrofuran / -78 - 25 °C View Scheme
参考文献
Johnson; Klein; Gillett; Wang; Song; Pino; Chandraratna
Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4764 - 4767
反应条件
1: Pd(PPh3)2Cl2, CuI, Et3N / 60 °C 2: K2CO3 / methanol 3: 64 percent / Pd(PPh3)2, CuI, Et3N / 25 °C View Scheme
参考文献
Johnson; Klein; Gillett; Wang; Song; Pino; Chandraratna
Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4764 - 4767
反应条件
copper monoiodide; bis(triphenylphosphine)palladium(II)-chloride
参考文献
Allergan, Inc.
Patent: US5489584 A1, 1996 ;
