7-溴-4,4-二甲基-1-四氢萘酮合成路线 （共 12 条）
反应条件
1: Pd(PPh3)2Cl2, CuI, Et3N / 60 °C 2: K2CO3 / methanol View Scheme
参考文献
Johnson; Klein; Gillett; Wang; Song; Pino; Chandraratna
Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4764 - 4767
反应条件
1: With 3,4,5,6-tetrahydro-1(2H)-pyrimidinone; 1,1-dimethylethylmagnesium chloride in tetrahydrofuran; diethyl ether
T=-20 - 20°C; 3 h;
2: With toluene-4-sulfonic acid in methanol
T=60°C; 3 h;
参考文献
Allergan Sales, Inc.
Patent: US6344561 B2, 2002 ;
Location in patent: Page column 99 ;
