4-[(5,6,7,8-四氢-5,5-二甲基-8-氧代-2-萘)乙炔]苯甲酸乙酯合成路线 （共 9 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine Ambient temperature;
参考文献
Johnson, Alan T.; Wang, Liming; Gillett, Samuel J.; Chandraratna, Roshantha A. S.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 4 p. 573 - 576
反应条件
copper monoiodide; bis(triphenylphosphine)palladium(II)-chloride in triethylamine
反应条件
1: 80 percent / AlCl3, Br2 / CH2Cl2 / 70 °C 2: Pd(PPh3)2Cl2, CuI, Et3N / 60 °C 3: K2CO3 / methanol 4: 64 percent / Pd(PPh3)2, CuI, Et3N / 25 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 4 p. 573 - 576
反应条件
1: Pd(PPh3)2Cl2, CuI, Et3N / 60 °C 2: K2CO3 / methanol 3: 64 percent / Pd(PPh3)2, CuI, Et3N / 25 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 4 p. 573 - 576
反应条件
1: K2CO3 / methanol 2: 64 percent / Pd(PPh3)2, CuI, Et3N / 25 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 4 p. 573 - 576
反应条件
1: 1.) NaN(SiMe3)2 / 1.) THF, -78 deg C, 2.) THF, from 0 deg C to RT 2: 1.) t-BuLi, 2.) ZnCl2, 3.) Pd(PPh3)4 View Scheme
参考文献
Johnson; Klein; Gillett; Wang; Song; Pino; Chandraratna
Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4764 - 4767
反应条件
sodium hexamethyldisilazane in tetrahydrofuran T=-78 - 25°C;
参考文献
Johnson, Alan T.; Wang, Liming; Gillett, Samuel J.; Chandraratna, Roshantha A. S.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 4 p. 573 - 576
参考文献
Allergan Sales, Inc.
Patent: US5877207 A1, 1999 ;
反应条件
sodium hexamethyldisilazane 1.) THF, -78 deg C, 2.) THF, from 0 deg C to RT; Yield given. Multistep reaction;
参考文献
Johnson; Klein; Gillett; Wang; Song; Pino; Chandraratna
Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4764 - 4767
