反应条件
1: 1.) LDA, 2.) TiCl4 3: Ph3P, diethyl azodicarboxylate / tetrahydrofuran / 5 h / Ambient temperature; also 6,6-dimethyl-9-hydroxy-10<2(R)-methyl-3(R)-hydroxybutyro>-4-propyl-2H,6H-benzo<1,2-b:3,4-b'>dipyran-2-one 4: 1.) CeCl3*7H2O, triphenylphosphine oxide, 2.) NaBH4 / 1.) EtOH, RT, 1 h, 2.) EtOH, -30 deg C, 5.5 h View Scheme
参考文献
Flavin, Michael T.; Rizzo, John D.; Khilevich, Albert; Kucherenko, Alla; Sheinkman, Abram K.; Vilaychack, Vilayphone; Lin, Lin; Chen, Wei; Greenwood, Eugenia Mata; Pengsuparp, Thitima; Pezzuto, John M.; Hughes, Stephen H.; Flavin, Thomas M.; Cibulski, Michael; Boulanger, William A.; Shone, Robert L.; Xu, Ze-Qi
Journal of Medicinal Chemistry, 1996 , vol. 39, # 6 p. 1303 - 1313
