2-甲基-4-(三氟甲基)-1,1-联苯合成路线 （共 16 条）
反应条件
potassium phosphate; [5-(3-butylbenzimidazol-2-yliden-1-yl)-25,26,27,28-tetrapropyloxy calix[4]arene] (pyridine) palladium(II) dibromide in 1,4-dioxane
T=100°C; 24 h; Inert atmosphere;
参考文献
Ren, Hui; Xu, Yong; Jeanneau, Erwann; Bonnamour, Isabelle; Tu, Tao; Darbost, Ulrich
Tetrahedron, 2014 , vol. 70, # 17 p. 2829 - 2837
反应条件
sodium carbonate; palladium diacetate in water
T=50°C; Suzuki reaction; 0.666667 h;
参考文献
Liu, Leifang; Zhang, Yuhong; Wang, Yanguang
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 6122 - 6125
反应条件
potassium fluoride; 18-crown-6 ether; bis-phenanthrylimidazolium chloride; palladium diacetate in tetrahydrofuran
T=50°C; Suzuki-Miyaura coupling; 12 h;
参考文献
Song, Chun; Ma, Yudao; Chai, Qiang; Ma, Chanqin; Jiang, Wei; Andrus, Merritt B.
Tetrahedron, 2005 , vol. 61, # 31 p. 7438 - 7446
反应条件
1: triallyl(2-methylphenyl)silane With tetrabutyl ammonium fluoride in tetrahydrofuran; water
T=20°C; 1 h;
2: 1-chloro-4-(trifluoromethyl)benzene With 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; bis(η3-allyl-μ-chloropalladium(II)) in tetrahydrofuran; water
T=80°C; 4 h;
参考文献
Sahoo, Akhila K.; Nakao, Yoshiaki; Hiyama, Tamejiro
Chemistry Letters, 2004 , vol. 33, # 5 p. 632 - 633
反应条件
N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in water; isopropyl alcohol
T=100°C; Suzuki coupling; 0.166667 h; microwave irradiation;
参考文献
Kabalka, George W.; Al-Masum, Mohammad
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6329 - 6331
反应条件
C30H26ClNNiP2 in tetrahydrofuran; toluene
T=23°C; Kumada Cross-Coupling; 8 h; Inert atmosphereSchlenk technique;
参考文献
Venkanna, Gopaladasu T.; Tammineni, Swetha; Arman, Hadi D.; Tonzetich, Zachary J.
Organometallics, 2013 , vol. 32, # 16 p. 4656 - 4663
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate; potassium carbonate in methanol
T=60°C; Suzuki-Miyaura coupling; 30 h; Inert atmosphereSealed tubesolid phase reaction;
参考文献
Colombel, Virginie; Presset, Marc; Oehlrich, Daniel; Rombouts, Frederik; Molander, Gary A.
Organic Letters, 2012 , vol. 14, # 7 p. 1680 - 1683
反应条件
cesium hydroxide; water; 1,4-di(diphenylphosphino)-butane; bis(η3-allyl-μ-chloropalladium(II)) in 1,4-dioxane; toluene
T=110°C; 24 h;
参考文献
Denmark, Scott E.; Ober, Michael H.
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1703 - 1714
参考文献
Shintaku, Tetsuya; Tanaka, Masahide; Shiratani, Hiroshi; Itaya, Nobushige
Patent: US2001/20110 A1, 2001 ;
反应条件
N-heterocyclic carbene-based nickel(II) complex in tetrahydrofuran
T=20°C; Kumada reaction; 12 h;
参考文献
Xi, Zhenxing; Liu, Bin; Chen, Wanzhi
Journal of Organic Chemistry, 2008 , vol. 73, # 10 p. 3954 - 3957
