2-甲基-4-(三氟甲基)-1,1-联苯合成路线 （共 16 条）
反应条件
potassium phosphate; Pd(OAc)2*3H2O in 1,4-dioxane
Suzuki-Miyaura cross-coupling; 12 h; Heating;
参考文献
Yu, Sai-Bo; Hu, Xiang-Ping; Deng, Jun; Huang, Jia-Di; Wang, Dao-Yong; Duan, Zheng-Chao; Zheng, Zhuo
Tetrahedron Letters, 2008 , vol. 49, # 7 p. 1253 - 1256
反应条件
sodium carbonate; trisphosphine-based palladium in water
T=100°C; Suzuki-Miyaura cross-coupling; 3 h;
参考文献
Yamada, Yoichi M. A.; Maeda, Yasunari; Uozumi, Yasuhiro
Organic Letters, 2006 , vol. 8, # 19 p. 4259 - 4262
反应条件
[PdCl2(AsPh3)2]; [AuCl(AsPh3)]; triphenyl-arsane; lithium chloride in acetonitrile
T=80°C; Stille Cross Coupling; 6 h; Inert atmosphere;
参考文献
Delpozo, Juan; Carrasco, Desiree; Perez-Temprano, Monica H.; Garcia-Melchor, Max; Alvarez, Rosana; Casares, Juan A.; Espinet, Pablo
Angewandte Chemie - International Edition, 2013 , vol. 52, # 8 p. 2189 - 2193
Angew. Chem., 2013 , vol. 125, # 8 p. 2245 - 2249
反应条件
sodium carbonate; 1-n-butyl-3-methylimidazolium hexafluorophosphate; palladium diacetate in water
T=60°C; Suzuki coupling; 1 h;
参考文献
Fernandez, Fernando; Cordero, Beatriz; Durand, Jerome; Muller, Guillermo; Malbosc, Franois; Kihn, Yolande; Teuma, Emmanuelle; Gomez, Montserrat
Dalton Transactions, 2007 , # 47 p. 5572 - 5581
反应条件
1.1: silicon tetrachloride / diethyl ether / -20 - 20 °C
2.1: 3.5 g / diethyl ether / 12 h / Heating
3.1: tetrabutylammonium fluoride trihydrate / tetrahydrofuran; H2O / 1 h / 20 °C
3.2: 78 percent / 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl / [(η3-C3H5)PdCl]2 / tetrahydrofuran; H2O / 4 h / 80 °C
View Scheme
参考文献
Sahoo, Akhila K.; Oda, Takuro; Nakao, Yoshiaki; Hiyama, Tamejiro
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1715 - 1727
反应条件
1.1: 3.5 g / diethyl ether / 12 h / Heating
2.1: tetrabutylammonium fluoride trihydrate / tetrahydrofuran; H2O / 1 h / 20 °C
2.2: 78 percent / 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl / [(η3-C3H5)PdCl]2 / tetrahydrofuran; H2O / 4 h / 80 °C
View Scheme
参考文献
Sahoo, Akhila K.; Oda, Takuro; Nakao, Yoshiaki; Hiyama, Tamejiro
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1715 - 1727
