methanol; sodium tetrahydroborate; diethyl methoxy borane in tetrahydrofuran; ethyl acetate T=-80 - -75°C; 5 h; Inert atmosphere; Product distribution / selectivity;

Corynebacterium acetoacidophilum ATCC13870 in dimethyl sulfoxide T=30°C; pH=7; 20 h; aerobic conditionspotassium phosphate buffer (pH 7.0); Product distribution / selectivity;

Candida famata var famata RIFY7455 in dimethyl sulfoxide T=30°C; pH=7; 20 h; aerobic conditionspotassium phosphate buffer (pH 7.0); Product distribution / selectivity;

Rhodotorula glutinis var dairenensis IFO0415 in dimethyl sulfoxide T=27°C; pH=7; 12 h; aerobic conditionspotassium phosphate buffer (pH 7.0); Product distribution / selectivity;

1.1: (S)-2-[N-(3-tert-butylsalicylidene)amino]-3-methyl-1-butanol; Ti(O-i-Pr)4 / CH2Cl2 / 62 h / -50 °C 1.2: aq. (COOH)2 / CH2Cl2 / 2 h / 20 °C 2.1: Et2BOMe / tetrahydrofuran; methanol / 0.25 h / -75 °C 2.2: NaBH4 / tetrahydrofuran; methanol / 3.5 h / -75 °C View Scheme

1.1: isopropyl alcohol / 25 - 82 °C 2.1: diisobutylaluminium hydride / toluene / 2 h / -60 - -50 °C / Inert atmosphere 2.2: 0.5 h / -50 - 30 °C 3.1: manganese(IV) oxide / toluene / 24 h / 25 - 30 °C 4.1: lithium hexamethyldisilazane / hexane; tetrahydrofuran / 1 h / -35 - -15 °C 4.2: 1 h / -80 - -75 °C 5.1: sodium hydroxide; water / tetrahydrofuran / 24 h / 20 - 30 °C 5.2: pH 1.5 - 2 5.3: 20 °C 6.1: hydrogenchloride; water / dichloromethane / 0 - 30 °C / pH 2 - 2.5 7.1: potassium iodide / N,N-dimethyl-formamide / 0.75 h / 25 - 65 °C / Inert atmosphere 7.2: 0.5 h / 60 - 65 °C 7.3: 0.5 h / 60 - 65 °C 8.1: dichloromethane / 3.25 h / 15 - 20 °C 9.1: zinc oxide / toluene / 2 h / 25 - 30 °C / Inert atmosphere 9.2: 12 h 10.1: hydrogenchloride; water / acetonitrile / 4 h / -10 °C 11.1: sodium tetrahydroborate; diethyl methoxy borane; methanol / ethyl acetate; tetrahydrofuran / 5 h / -80 - -75 °C / Inert atmosphere View Scheme

1.1: hydrogenchloride; water / dichloromethane / 0 - 30 °C / pH 2 - 2.5 2.1: potassium iodide / N,N-dimethyl-formamide / 0.75 h / 25 - 65 °C / Inert atmosphere 2.2: 0.5 h / 60 - 65 °C 2.3: 0.5 h / 60 - 65 °C 3.1: dichloromethane / 3.25 h / 15 - 20 °C 4.1: zinc oxide / toluene / 2 h / 25 - 30 °C / Inert atmosphere 4.2: 12 h 5.1: hydrogenchloride; water / acetonitrile / 4 h / -10 °C 6.1: sodium tetrahydroborate; diethyl methoxy borane; methanol / ethyl acetate; tetrahydrofuran / 5 h / -80 - -75 °C / Inert atmosphere View Scheme

1.1: zinc oxide / toluene / 2 h / 25 - 30 °C / Inert atmosphere 1.2: 12 h 2.1: hydrogenchloride; water / acetonitrile / 4 h / -10 °C 3.1: sodium tetrahydroborate; diethyl methoxy borane; methanol / ethyl acetate; tetrahydrofuran / 5 h / -80 - -75 °C / Inert atmosphere View Scheme

1.1: potassium iodide / N,N-dimethyl-formamide / 0.75 h / 25 - 65 °C / Inert atmosphere 1.2: 0.5 h / 60 - 65 °C 1.3: 0.5 h / 60 - 65 °C 2.1: dichloromethane / 3.25 h / 15 - 20 °C 3.1: zinc oxide / toluene / 2 h / 25 - 30 °C / Inert atmosphere 3.2: 12 h 4.1: hydrogenchloride; water / acetonitrile / 4 h / -10 °C 5.1: sodium tetrahydroborate; diethyl methoxy borane; methanol / ethyl acetate; tetrahydrofuran / 5 h / -80 - -75 °C / Inert atmosphere View Scheme

1.1: dichloromethane / 3.25 h / 15 - 20 °C 2.1: zinc oxide / toluene / 2 h / 25 - 30 °C / Inert atmosphere 2.2: 12 h 3.1: hydrogenchloride; water / acetonitrile / 4 h / -10 °C 4.1: sodium tetrahydroborate; diethyl methoxy borane; methanol / ethyl acetate; tetrahydrofuran / 5 h / -80 - -75 °C / Inert atmosphere View Scheme