alpha-甲基-L-色氨酸合成路线 （共 14 条）
反应条件
1: With CsOH; water in ethanol T=70°C; 4 h; 2: With hydrogenchloride in water
参考文献
Lu, Ta-Jung; Lin, Cheng-Kun
Journal of Organic Chemistry, 2011 , vol. 76, # 6 p. 1621 - 1633
反应条件
hydrogenchloride in methanol Heating;
参考文献
Gander-Goquoz; Seeback
Helvetica Chimica Acta, 1988 , vol. 71, # 1 p. 224 - 236
反应条件
α-chymotrypsin in water T=37°C; 40 h; pH=5.0;
参考文献
Tetrahedron Letters, , vol. 23, # 33 p. 3335 - 3336
反应条件
α-chymotrypsin in water T=37°C; 40 h; also other α-methyl-amino acid esters investigated; Product distribution;
参考文献
Anantharamaiah, G. M.; Roeske, Roger W.
Tetrahedron Letters, 1982 , vol. 23, # 33 p. 3335 - 3336
反应条件
1: CF3COOH / 96 h / Ambient temperature 2: Na2CO3 / dioxane; H2O / 0 °C 3: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 1 h, 2.) THF, a) -78 deg C, 1 h, b) from -78 deg C to RT, 2 h 4: trifluoroacetic acid / 1.5 h / Ambient temperature 5: H2 / 10percent Pd/C / ethanol / 3 h / Ambient temperature View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 39, # 12 p. 1019 - 1038
反应条件
1: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 1 h, 2.) THF, a) -78 deg C, 1 h, b) from -78 deg C to RT, 2 h 2: trifluoroacetic acid / 1.5 h / Ambient temperature 3: H2 / 10percent Pd/C / ethanol / 3 h / Ambient temperature View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 39, # 12 p. 1019 - 1038
反应条件
1: trifluoroacetic acid / 1.5 h / Ambient temperature 2: H2 / 10percent Pd/C / ethanol / 3 h / Ambient temperature View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 39, # 12 p. 1019 - 1038
反应条件
1: Cs2CO3 / dimethylformamide 2: CF3COOH / 96 h / Ambient temperature 3: Na2CO3 / dioxane; H2O / 0 °C 4: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 1 h, 2.) THF, a) -78 deg C, 1 h, b) from -78 deg C to RT, 2 h 5: trifluoroacetic acid / 1.5 h / Ambient temperature 6: H2 / 10percent Pd/C / ethanol / 3 h / Ambient temperature View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 39, # 12 p. 1019 - 1038
反应条件
potassium hydroxide; potassium phosphate buffer; porcine kidney acylase I T=40°C; relative initial rate of hydrolysis, also with Aspergillus acylase I as a catalyst; with or without CoCl2;
参考文献
Journal of the American Chemical Society, , vol. 111, # 16 p. 6354 - 6364
反应条件
1: 1.) HMPT, LDA / 1.) THF, -78 deg C, 40 min, 2.) THF, -78 deg C, 36 h 2: 59 percent / 1N MeONa / methanol / 24 h / Ambient temperature 3: 87 percent / 6N HCl / methanol / Heating View Scheme
参考文献
Helvetica Chimica Acta, , vol. 71, # 1 p. 224 - 236
